Content-based image retrieval (CBIR) is broadly applicable for searching digital images from a gigantic database. Images are retrieved by their primitive visual contents such as color, texture, shape, and spatial layout. The approach presented in this paper utilizes structural connections within an image by integrating textured color descriptors and structure descriptors to retrieve semantically significant images. The retrieval results were obtained by applying the HSV histogram, color coherence vector, and local binary pattern histogram to the standard database of Wang et al., which has 1000 images of 10 different semantic categories. Euclidean distance was used to find the similarity between the query image and database images. This method was evaluated against different methods based on edge histogram descriptors, color structure descriptors, color moments, the color histogram, the HSV histogram, Tamura features, edge descriptors, geometrical shape attributes, and statistical properties such as mean, variance, skewness, and kurtosis. Retrieval results obtained using the proposed methods demonstrated a significant improvement in the average precision (73.8% and 73.1%) compared with those obtained using other existing retrieval methods.