Multi-photon polymerization of bio-inspired, thymol-functionalized hybrid materials with biocompatible and antimicrobial activity

Parkatzidis, Kostas; Chatzinikolaidou, Μaria; Koufakis, Eleftherios; Kaliva, Maria; Farsari, Maria; Vamvakaki, Maria

doi:10.1039/d0py00281j

Cited by 23 publications

(19 citation statements)

References 36 publications

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“…These silicate-based materials, characterized by an inorganic (-Si-O-Si-) backbone functionalized with organic groups such as acrylates or epoxides, have been traditionally used for photonics [ 37 ], but they are now attracting interest for biotechnological applications. The organic side chains cross-link the resin into a durable and biocompatible solid material [ 39 , 40 ]. Always based on silicate materials, polydimethylsiloxane (PDMS) [ 41 ] is a widely used material to build microfluidic systems and micro-optics [ 42 ] that can be polymerized by means of MPA.…”

Section: Light Interaction With Soft Mattermentioning

confidence: 99%

Multiphoton Laser Fabrication of Hybrid Photo-Activable Biomaterials

Bouzin

Zeynali

Marini

et al. 2021

Sensors

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The possibility to shape stimulus-responsive optical polymers, especially hydrogels, by means of laser 3D printing and ablation is fostering a new concept of “smart” micro-devices that can be used for imaging, thermal stimulation, energy transducing and sensing. The composition of these polymeric blends is an essential parameter to tune their properties as actuators and/or sensing platforms and to determine the elasto-mechanical characteristics of the printed hydrogel. In light of the increasing demand for micro-devices for nanomedicine and personalized medicine, interest is growing in the combination of composite and hybrid photo-responsive materials and digital micro-/nano-manufacturing. Existing works have exploited multiphoton laser photo-polymerization to obtain fine 3D microstructures in hydrogels in an additive manufacturing approach or exploited laser ablation of preformed hydrogels to carve 3D cavities. Less often, the two approaches have been combined and active nanomaterials have been embedded in the microstructures. The aim of this review is to give a short overview of the most recent and prominent results in the field of multiphoton laser direct writing of biocompatible hydrogels that embed active nanomaterials not interfering with the writing process and endowing the biocompatible microstructures with physically or chemically activable features such as photothermal activity, chemical swelling and chemical sensing.

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Section: Light Interaction With Soft Mattermentioning

confidence: 99%

Multiphoton Laser Fabrication of Hybrid Photo-Activable Biomaterials

Bouzin

Zeynali

Marini

et al. 2021

Sensors

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“…The best-known example is two-photon stereolithography (TPS). The use of TPS in molecular imprinting is relatively new, even though the technique has already been reported in several different applications such as scaffolding for cells, , shape-shifting of microstructures for proteins, biocompatible hybrid materials, tomography, and optics. , This technique was first applied to the synthesis of MIPs by Chia Gomez et al, who showed its versatility by fabricating different structures such as grids, dot arrays and cantilevers smaller than 60 μm (Figure ). Lucirin TPO was used as a photoinitiator for a laser wavelength of 800 nm.…”

Section: Photostructuring Mipsmentioning

confidence: 99%

Photopolymerization and Photostructuring of Molecularly Imprinted Polymers

Paruli

Soppera

Haupt

et al. 2021

ACS Appl. Polym. Mater.

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Over the past few decades, molecularly imprinted polymers (MIPs) have become extremely attractive materials for biomimetic molecular recognition due to their excellent affinity and specificity, combined with robustness, easy engineering, and competitive costs. MIPs are synthetic antibody mimics obtained by the synthesis of 3D polymer networks around template molecules, thus generating specific binding cavities. Numerous efforts have been made to improve the performances and the versatility of MIPs, with a special focus on ways to control their size, morphology, and physical form for a given application. Gaining control over these parameters has allowed MIPs to adopt a defined micro- and nanostructure, providing access to nanocomposites and micro/nanosystems, with fine-tuned properties, which become critical for modern applications ranging from chemical sensing to bioimaging and medical therapy. In this rich and complex context, light as a cheap and versatile source of energy has emerged as a powerful tool for structuring MIPs. This review presents the most recent advances on structuring MIPs at the nano/microscale, using light as a stimulus to trigger the polymerization process. Thus, after a general introduction on radical polymerization of MIPs, with a special emphasis on photopolymerization by UV and visible light, the reader will be presented with ways of structuring MIPs by processes that are inherently spatially confined, such as localized photopolymerization and lithographic techniques, supported by representative examples and complemented with a final outlook on future trends in this field.

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“…amino acids, and include primary amine (-NH 2 ), carboxylic acid (-COOH), thiol (-SH), and carbonyl (-CHO) functionalities. Complex microstructures have been already produced from modified thymol [177], cellulose-based compounds [178], functionalized gelatin and chitosan blends [176], silk-based compounds [179,180], hyaluronic acid [181], and dextran derivatives [182]. Even photoinitiator-free systems of biobased materials [44,45] were applied in MPL technology, which has made it possible to eliminate toxic photoinitiators commonly used in photo cross-linking reactions.…”

Section: Renewablesmentioning

confidence: 99%

“…The functionalization of materials used for 3D structuring by MPL has been studied for biomedical applications. Functionalization with proteins [230] and thymol [177] are only two examples that have been reported very recently.…”

Section: Functionalizedmentioning

confidence: 99%

Photopolymerization Mechanisms at a Spatio-temporally Ultra-confined Light

Skliutas¹,

Lebedevaite²,

Kabouraki³

et al. 2020

Preprint

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Ultrafast laser 3D lithography based on non-linear light-matter interactions, widely known as multi-photon lithography (MPL), offers unrivaled precision rapid prototyping and flexible additive manufacturing options. 3D printing equipment based on MPL are already commercially available, yet there is still no comprehensive understanding of factors determining spatial resolution, accuracy, fabrication throughput, repeatability, and standardized metrology methods for the accurate characterization of the produced 3D objects and their functionalities. The photoexcitation mechanisms, spatial-control or photo-modified volumes, and the variety of processable materials are topics actively investigated. The complexity of the research field is underlined by limited understanding and fragmented knowledge of light-excitation and material response. Research to date has only provided case-specific findings on photoexcitation, chemical modification, and material characterization of the experimental data. In this review, we aim to provide a consistent and comprehensive summary of the existing literature on photopolymerization mechanisms under highly confined spatial and temporal conditions, where, besides the excitation and cross-linking, parameters such as diffusion, temperature accumulation, and the finite amount of monomer molecules start to become of critical importance. Key parameters such as, photoexcitation, polymerization kinetics, and the properties of the additively manufactured materials at the nanoscale in 3D are examined, whereas, the perspectives for future research and as well as emerging applications are outlined.

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Multi-photon polymerization of bio-inspired, thymol-functionalized hybrid materials with biocompatible and antimicrobial activity

Abstract: Thymyl-methacrylate functionalized, hybrid 3D scaffolds, fabricated by multi-photon lithography, exhibit excellent biocompatibility and antimicrobial action for bone and dental tissue engineering.

Cited by 23 publications

References 36 publications

Multiphoton Laser Fabrication of Hybrid Photo-Activable Biomaterials

Multiphoton Laser Fabrication of Hybrid Photo-Activable Biomaterials

Photopolymerization and Photostructuring of Molecularly Imprinted Polymers

Photopolymerization Mechanisms at a Spatio-temporally Ultra-confined Light

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