Multi‐Pathway Microenvironment Regulation for Atherosclerosis Therapy Based on Beta‐Cyclodextrin/L‐Arginine/Au Nanomotors with Dual‐Mode Propulsion

Wu, Ziyu; Wu, Rui; Li, Xiaoyun; Wang, Xingwen; Tang, Xueting; Tan, Kaiyuan; Wan, Mimi; Mao, Chun; Xu, Xingquan; Jiang, Huiming; Li, Jiawei; Zhou, Min; Shi, Dongquan

doi:10.1002/smll.202104120

Cited by 29 publications

(30 citation statements)

References 66 publications

(41 reference statements)

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“…[194][195][196] β-Cyclodextrin (CD) is a highly efficient CC solubilizer. [197,198] Zhang et al developed a supramolecular nanoassembly (pCD/pBM-SNA) using self-assembling polyβ-CD (pCD, a lysosomal CC solubilizer) and dextran sulfate grafted with benzimidazole (BM, a pH-sensitive switch pBM) for removing lysosomal CCs from cholesterol-containing cells in atherosclerotic plaques. [199] As shown in Figure 8A, hydrophobic BM can efficiently seal the CD cavity in pCD/ pBM-SNA at pH 7.4 (switch OFF), and pCD/pBM-SNA disassembles (Figure 8B) to switch on the CD cavity under acidic conditions because of the protonation of BM.…”

Section: Ph Responsivenessmentioning

confidence: 99%

Biomarker‐Responsive Nanosystems for Chronic Disease Theranostics

Wang

et al. 2022

Adv Funct Materials

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Chronic diseases claim millions of lives every year, and it is of great significance to explore and develop advanced drugs to improve the cure rate of chronic diseases. Nanotheranostics are innovative strategies that enable the integration of diagnostic and therapeutic properties into a single nanosystem. Despite great success in nanotheranostics, their applications of nanotheranostics in nanomedicine are still in their infancy. This is because each disease has its corresponding characteristic pathological microenvironment, which motivates the development of endogenous biomarker-responsive nanosystems to meet the requirements of diagnosis and treatment. Herein, recent progress is presented in biomarker-responsive nanosystems and their biomedical applications. First, biomarker-responsive nanosystems are classified into eight subsections according to the type of chronic diseases, including tumors, cardiovascular diseases, neurological diseases, Wilson's diseases, chronic liver diseases, chronic kidney diseases, diabetes mellitus, and rheumatoid arthritis. In the following, a variety of intriguing applications of biomarkers-responsive nanosystems are briefly elaborated, such as biosensing, diagnosis, therapy, combined theranostics, and early evaluation of therapy effect, etc. Finally, the challenges and future directions from research to clinical translation of these responsive nanosystems are also presented.

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Section: Ph Responsivenessmentioning

confidence: 99%

Biomarker‐Responsive Nanosystems for Chronic Disease Theranostics

Wang

et al. 2022

Adv Funct Materials

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“…The hybrid nano/micromotor, mixing two propulsion mechanisms, can combine the advantages of both to improve drug delivery efficiency and therapeutic effect. Wu et al [ 79 ] constructed a nanomotor with bi-propulsion by utilizing the covalent binding and self-assembly of β-cyclodextrin(β-CD) and L-arginine (LA) immobilized with Au nanoparticles ( Table 3 ). It used an anti-VCAM-1 monoclonal antibody (aV) to target damaged blood vessels, and NIR laser irradiation, as a driving force, ablated inflammatory macrophages through a photothermal effect.…”

Section: Nano/micromotors In Blood Vesselsmentioning

confidence: 99%

Applications of Nano/Micromotors for Treatment and Diagnosis in Biological Lumens

et al. 2022

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Natural biological lumens in the human body, such as blood vessels and the gastrointestinal tract, are important to the delivery of materials. Depending on the anatomic features of these biological lumens, the invention of nano/micromotors could automatically locomote targeted sites for disease treatment and diagnosis. These nano/micromotors are designed to utilize chemical, physical, or even hybrid power in self-propulsion or propulsion by external forces. In this review, the research progress of nano/micromotors is summarized with regard to treatment and diagnosis in different biological lumens. Challenges to the development of nano/micromotors more suitable for specific biological lumens are discussed, and the overlooked biological lumens are indicated for further studies.

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“…[3][4][5] However, the intravascular stents as foreign objects are highly likely to cause thrombosis, inflammatory infiltration, vascular smooth muscle cell phenotype disorders, extracellular matrix deposition, etc., which leads to in-stent restenosis (ISR) after surgery and seriously influences the long-term effects. [6][7][8] To solve this problem, various strategies have been developed, such as synchronous application of oral drugs and coating stents with functional molecules. [9,10] Although with many improvements to reduce the incidence of ISR, the former method faces the limitations of untargeted and random drug diffusion [11][12][13][14] ; while the latter has problems like low coating amount, and low coating coverage, thus cannot prevent smooth muscle hyperplasia or restenosis comprehensively.…”

Section: Introductionmentioning

confidence: 99%

Bioinspired Vascular Stents with Microfluidic Electrospun Multilayer Coatings for Preventing In‐Stent Restenosis

Cheng

Zhang

et al. 2022

Adv Healthcare Materials

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In‐stent restenosis (ISR) is seriously affecting the long‐term prognosis of vascular interventional therapy and leading to enormous medical burdens. Great efforts have been devoted to developing functional vascular stents with desired features and properties for effective ISR prevention. Here, a multifunctional bionic vascular stent with designed coatings prepared using microfluidic electrospinning technology is presented. Such stents are composed of biocompatible, drug‐loaded methylacrylated gelatin‐polyethylene glycol diacrylate (GelMA‐PEGDA) and polycaprolactone composite nanofibers on 316L stainless steel stents by an easy‐to‐operate step‐by‐step spraying method. Benefitting from the addition of polydopamine during the fabrications, the drug‐loaded composite nanofibers can adhere well to both the stent and the vascular wall. Furthermore, as the inner fibrous layer of the stent contacting the lumen is equipped with heparin‐vascular endothelial growth factor (Hep‐VEGF), it plays an anticoagulation role and promotes the growth of endothelial cells; while the outer layer contacts the vascular wall and releases rapamycin slowly, which can restrain smooth muscle proliferation. By implanting this into the rabbit carotid artery, the multi‐functional bionic demonstrates that the vascular stent can achieve good anti‐thrombosis and in‐stent restenosis effects, which indicates its potential values in vascular intervention and other biomedical fields.

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Multi‐Pathway Microenvironment Regulation for Atherosclerosis Therapy Based on Beta‐Cyclodextrin/L‐Arginine/Au Nanomotors with Dual‐Mode Propulsion

Abstract: hoc test or Dunnett's T3 post hoc test was used in one-way ANOVA. p < 0.05 was considered statistically significant (*p < 0.05).

Cited by 29 publications

References 66 publications

Biomarker‐Responsive Nanosystems for Chronic Disease Theranostics

Biomarker‐Responsive Nanosystems for Chronic Disease Theranostics

Applications of Nano/Micromotors for Treatment and Diagnosis in Biological Lumens

Bioinspired Vascular Stents with Microfluidic Electrospun Multilayer Coatings for Preventing In‐Stent Restenosis

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