“…MR imaging, particularly using multiparametric quantitative techniques (T 1 , T 2 and T 2 * relaxation time measurements, diffusion and magnetization transfer ratio measurements), and MR spectroscopy have been widely used to explain the disease's physiopathology mechanisms including those of observed in the normal appearing white matter (Reitz et al, 2016). In recent years, NMR or mass spectrometry metabolomics, has been used to investigate the metabolite changes in only cerebrospinal fluid which reflects the tissue inflammation associated with EAE (Smolinska et al, 2011;Blanchet et al, 2011;Smolinska et al, 2012;Noga et al, 2012;Lutz et al, 2013;Gebregiworgis et al, 2013;Mangalam et al, 2013;Coulier et al, 2013;Cocco et al, 2015;Dickens et al, 2015;Poisson et al, 2015) or MS (Sinclair et al, 2010;Lutz et al, 2007;Villostada et al, 2017;Bhargava and Calabresi, 2016;Pieragostino et al, 2015;Dickens et al, 2014;Reinke et al, 2014;Vingara et al, 2013;Moussalieh et al, 2014).…”