Multi-parameter phenotyping of platelets and characterisation of the effects of agonists using machine learning
Ami Vadgama,
James Boot,
Harriet E. Allan
et al.
Abstract:BackgroundPlatelets are crucial for thrombosis and haemostasis, with their function driven by the expression of specialised surface markers. The concept of distinct circulating sub-populations of platelets has emerged in recent years, but their exact nature remains debatable. We reasoned that a more comprehensive characterisation of surface marker changes at rest and upon activation would be valuable in determining this.ObjectiveTo use a full spectrum flow cytometry-based panel, together with parameters of phy… Show more
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