Multi-parameter flow cytometry immunophenotyping distinguishes different stages of tuberculosis infection

Estévez, Olivia; Anibarro, Luis; Garet, Elina; Martı́nez, Antonio; Peña, Alberto; Barcia, Laura; Peleteiro, Mercedes; González-Fernández, África

doi:10.1016/j.jinf.2020.03.064

Cited by 28 publications

(20 citation statements)

References 63 publications

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“…BCG vaccination and M. tuberculosis infections are suggested to transiently enhance MAIT cell frequency in rhesus macaques (56), similar to transient MAIT cell responses to BCG vaccination in humans (55). This early MAIT cell response in vivo is consistent to the innate-like activation program of MAIT cells in this study, although the kinetics, trends, and distributions of MAIT cells or their activation in human M. tuberculosis infections requires further investigations (7,(96)(97)(98). Second, we observed that both BCG and avirulent H37Ra similarly activated primary human MAIT cells.…”

Section: Discussionsupporting

confidence: 75%

Mucosal-Associated Invariant T Cells Develop an Innate-Like Transcriptomic Program in Anti-mycobacterial Responses

et al. 2020

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Section: Discussionsupporting

confidence: 75%

Mucosal-Associated Invariant T Cells Develop an Innate-Like Transcriptomic Program in Anti-mycobacterial Responses

et al. 2020

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“…Moreover, some studies have shown that HLA-DR and Ki-67 expression on Mtbspecific CD4 T + cells correlate positively with mycobacterial load and expression is reduced after treatment [24][25][26]. The enhanced expression of Ki-67 by the CD4 + and CD8 + T cell subsets from PTM patients in response to in vitro re-stimulation with Mtb antigens is a reflection of higher mycobacteria antigenic burden in slow responders, which also suggests that the incidence of PTM may be a chronic infectious disease with congenital and acquired immune participation in the response to tuberculous antigens.…”

Section: Discussionmentioning

confidence: 99%

Immune Dysfunction of T Lymphocytes may be a Risk Factor for Pleurisy Tuberculoma

Gao¹,

Yang²,

Ji³

et al. 2021

Preprint

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Background: Pleurisy tuberculoma (PTM) is a benign proliferative disease that occurs most commonly after effective treatment of tuberculous pleurisy. In this study, we investigated the risk factors for PTM. Methods: The data of 56 consecutive tuberculoma patients treated at the Nanjing Thoracic Hospital and the Second Hospital between March 2013, and April 2020, were extracted from the hospital database and reviewed retrospectively. Sixty patients treated effectively for tuberculous pleurisy without PTM were included as the control group as most cases of PTM have a history of tuberculous pleurisy. We analyzed the clinical characteristics, laboratory examination results, and imaging features to identify potential risk factors for PTM.Results: The mean age of the PTM patients was 29.04 ± 6.95 years, with no difference between males and females. The onset of PTM was 4.29 ± 2.34 months from the diagnosis of tuberculous pleurisy. The PTM lesions were more commonly located in the lower lobes with no difference in the left and right lung distribution. There were no significant differences in the presenting symptoms and underlying disease of the patients in the PTM and control groups. Pleural thickening was more common in the PTM group (44.64% vs. 23.33% respectively, P = 0.015) and ADA activity was higher (48.32± 19.19 vs. 44.79± 24.57) compared with the control group. There were no significant differences between the groups in terms of the absolute numbers of CD4 + and CD8+ T lymphocyte cells or the CD4+/CD8+ T cell ratio (P > 0.05 ). Expression of the activation marker Ki-67 on CD4+ and CD8+ T cells was significantly increased in the PTM group compared with the control group (P < 0.05).Conclusions: Our results indicate that dysregulation of T lymphocytes may be a potential risk factor for PTM.

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“…55,56 In contrast, a recent study showed that IFN-γ production by circulating MAIT-cells in response to Mtb was higher in active TB patients and LTBI compared with uninfected contacts, although LTBI showed highest IFN-γ production, suggesting a possible role for MAIT-cells in infection control. 57 In another study, MAIT-cells isolated from tuberculous pleural effusions displayed increased cytokine and cytotoxic responses to Mtb-derived antigens compared with blood MAIT-cells, mainly mediated by IL-2, IL-12, and IL-18…”

Section: Contribution Of Mait-cells To Protective Immunity Against Mycobacterial Infectionsmentioning

confidence: 97%

The role of donor‐unrestricted T‐cells, innate lymphoid cells, and NK cells in anti‐mycobacterial immunity

Ruibal

Voogd

Joosten

et al. 2021

Immunological Reviews

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Multi-parameter flow cytometry immunophenotyping distinguishes different stages of tuberculosis infection

Cited by 28 publications

References 63 publications

Mucosal-Associated Invariant T Cells Develop an Innate-Like Transcriptomic Program in Anti-mycobacterial Responses

Mucosal-Associated Invariant T Cells Develop an Innate-Like Transcriptomic Program in Anti-mycobacterial Responses

Immune Dysfunction of T Lymphocytes may be a Risk Factor for Pleurisy Tuberculoma

The role of donor‐unrestricted T‐cells, innate lymphoid cells, and NK cells in anti‐mycobacterial immunity

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