Multi-organ toxicity and death following acute unintentional inhalation of paint thinner fumes

Zaidi, S. S. A.; Shaw, Asha N.; Patel, Monila N.; Shah, Vishva; Rajendran, Dipa; Shah, Bhavini; Sinha, Sukesh Narayan; Gandhi, Sumitra J.; Saiyed, H. N.

doi:10.1080/15563650601031791

Cited by 7 publications

(7 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus the toxicological implications from these exposures cannot be pinpoint at this stage. Multi-organ toxicity causing death of a male paint worker accidentally exposed to solvent fumes from thinner has recently been described by us 17) .…”

Section: Resultsmentioning

confidence: 99%

Neurobehavioral Effects and Hormones Profile among Spray Painters

et al. 2006

View full text Add to dashboard Cite

A cross-sectional study was conducted in 25 spray painters and 35 control subjects to evaluate neurobehavioral function, and thyroid and reproductive hormones profile. This study indicated higher prevalence of psychological and neurological symptoms, and clinical findings among spray painters when compared with controls. Levels of TSH were significantly (p<0.01) elevated in spray painters over the control group (3.04 ± 1.53 vs 1.88 ± 1.07 µ µ µ µ µIU/ml, mean ± SD), respectively.Two of the 25 spray painters acquired sub-clinical hypothyroidism, and one subject was detected with overt hypothyroidism. T 4 levels were significantly (p<0.05) suppressed in spray painters while T 3 was not changed significantly in both the groups. Reproductive hormones (LH, FSH, and testosterone) showed no significant changes in control and spray-painting group. However, two spray painters had abnormally high level of LH (26.43 and 12.22 IU/l; normal range 0.5-10 IU/l). These subjects were also found to have abnormally higher level of FSH (38.63 and 14.11 IU/l; normal range 1.3-11.5 IU/l). An isolated higher level of FSH (39.94 IU/l) was also observed in one spray painter. No abnormality in the level of LH was observed in control group while 3 subjects from this group had abnormally high level of FSH. Testosterone levels were under the normal range (3-12 ng/ ml) in both the groups. This study might suggest that spray painters are at risk of developing neurobehavioral, thyroid and reproductive problems.

show abstract

Section: Resultsmentioning

confidence: 99%

Neurobehavioral Effects and Hormones Profile among Spray Painters

et al. 2006

View full text Add to dashboard Cite

show abstract

“…Chronic use causes permanent damage in the central nervous system, heart, liver and lungs, and kidneys. 1,[6][7][8][9][10][11] Abuse of thinner has become a growing health issue in our country too. 12 This study was therefore conducted to determine the histological changes of kidney with exposure to chronic thinner inhalation.…”

Section: Introductionmentioning

confidence: 99%

Histopathological Changes of Rat Kidney with Exposure to Chronic Thinner Inhalation

Toros¹,

Toros

Aker

et al. 2011

Renal Failure

View full text Add to dashboard Cite

Introduction: Organic solvents are liquid substances commonly used in everyday life at home and in industrial workplaces. These solvents are found primarily in paint as thinner. Because other narcotics are hard to find, thinner is used as a narcotic especially among youngsters of low socioeconomic level. The aim of this study is to determine the histopathological changes of rat kidney with exposure to chronic thinner inhalation. Methods: Randomized trial -the study was conducted at the animal care facility of Haydarpasa Numune Education and Research Hospital. Forty albino Wistar male rats were used throughout the experiment. Three groups of rats inhaled thinner in a glass cage for 1, 3, and 5 weeks, respectively. Ten rats inhaled only the air in the room as the control group. Results: We observed the development of inflammation in the kidneys that became more remarkable as exposure time extended. Development of inflammation because of thinner apparently differed between the groups of week 1 and week 5. There was no difference in granuloma development. If the experiment lasted longer, there might have been granuloma development. Conclusions: Based on histopathological evaluations, it was shown that exposure to chronic thinner inhalation causes detectable damage on the kidney, which becomes more prominent as exposure period extends. As we established disorders in movement and consciousness in the rats during thinner inhalation, we can conclude that thinner also has a damaging effect upon the central nervous system.

show abstract

“…Most of the solvents are volatile at room temperature and have considerable potential for toxicity (intentional by abuse or unintentional due to occupational exposure) by inhalation (Zaidi et al, 2007). As a result, concerns about health effects from exposure(s) to these agents led to a shift in their potential use by (professional) painters.…”

Section: Discussionmentioning

confidence: 99%

“…One of the two major groups of paints is latex paints (wherein the resin is acrylic-, vinyl-, or styrene-based and the solvent is water); the other is oil-based resin paints and the solvent is petroleum-based/organic (like toluene or xylene) (Scélo et al, 2009). These (and other commonly used) solvents are volatile at room temperature and have considerable potential for toxicity (during occupational exposure) by inhalation (Zaidi et al, 2007).…”

Section: Introductionmentioning

confidence: 99%