Multi-Organ Failure in a Patient With Diabetes due to COVID-19 With Clear Lungs

Kabashneh, Sohaip; Ali, Hammad; Alkassis, Samer

doi:10.7759/cureus.8147

Cited by 14 publications

(19 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… b Only data of patients with isolated DKA has been shown. c Individual data on patient sex were available in 102 patients from 18 studies [ [7] , [8] , [9] , [10] , [11] , [12] , [13] , [14] , [15] , [16] , [18] , [19] , [20] , [21] , [22] , [23] , [24] , 28 ]. d Individual data on patient ethnicity were available in 84 patients from 4 studies [ 9 , 10 , 22 , 28 ].…”

Section: Resultsmentioning

confidence: 99%

“… c Individual data on patient sex were available in 102 patients from 18 studies [ [7] , [8] , [9] , [10] , [11] , [12] , [13] , [14] , [15] , [16] , [18] , [19] , [20] , [21] , [22] , [23] , [24] , 28 ]. …”

Section: Resultsmentioning

confidence: 99%

“…Four patients had thromboembolic events [ 11 , 15 , 18 , 20 ]. Data on the final outcome (in terms of discharged, deceased, or hospitalized) was available for 78 patients [ [7] , [8] , [9] , [10] , [11] , [12] , [13] , [14] , [15] , [16] , [18] , [19] , [20] , [21] , 23 , 24 , 28 ]. Among these 78 patients, 41 (52.5%) were discharged, 35 (45.0%) were deceased and 2 (2.5%) had remained hospitalized.…”

Section: Resultsmentioning

confidence: 99%

“…As with other severe infections [ 6 ], diabetic ketoacidosis (DKA) has been reported in patients with COVID-19 [ [7] , [8] , [9] , [10] , [11] , [12] , [13] , [14] , [15] , [16] , [17] , [18] , [19] , [20] , [21] , [22] , [23] , [24] ]. With regard to coronaviruses, it has been shown that SARS-CoV (responsible for the SARS outbreak in 2003) binds to ACE2 in the pancreatic islets leading to islet damage and acute diabetes [ 25 ].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Clinical profile and outcomes in COVID-19 patients with diabetic ketoacidosis: A systematic review of literature

Pal

Banerjee

Yadav

et al. 2020

Diabetes & Metabolic Syndrome: Clinical Research & Revi

View full text Add to dashboard Cite

Background and aim To conduct a systematic literature review and analyze the demographic/biochemical parameters and clinical outcomes of COVID-19 patients with diabetic ketoacidosis (DKA) and combined DKA/HHS (hyperglycemic hyperosmolar syndrome). Methods PubMed, Scopus, Embase, and Google Scholar databases were systematically searched till August 3, 2020 to identify studies reporting COVID-19 patients with DKA and combined DKA/HHS. A total of 19 articles reporting 110 patients met the eligibility criteria. Results Of the 110 patients, 91 (83%) patients had isolated DKA while 19 (17%) had DKA/HHS. The majority of the patients were male (63%) and belonged to black ethnicity (36%). The median age at presentation ranged from 45.5 to 59.0 years. Most of the patients (77%) had pre-existing type 2 diabetes mellitus. Only 10% of the patients had newly diagnosed diabetes mellitus. The median blood glucose at presentation ranged from 486.0 to 568.5 mg/dl, being higher in patients with DKA/HHS compared to isolated DKA. The volume of fluid replaced in the first 24 h was higher in patients with DKA/HHS in contrast to patients with DKA alone. The in-hospital mortality rate was 45%, with higher mortality in the DKA/HHS group than in the isolated DKA group (67% vs. 29%). pH was lower in patients who had died compared to those who were discharged. Conclusion DKA in COVID-19 patients portends a poor prognosis with a mortality rate approaching 50%. Differentiating isolated DKA from combined DKA/HHS is essential as the latter represents nearly one-fifth of the DKA cases and tends to have higher mortality than DKA alone.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Clinical profile and outcomes in COVID-19 patients with diabetic ketoacidosis: A systematic review of literature

Pal

Banerjee

Yadav

et al. 2020

Diabetes & Metabolic Syndrome: Clinical Research & Revi

View full text Add to dashboard Cite

show abstract

“…SARS-CoV-2 infection causes the release of a significant amount of pro-inflammatory cytokines that aggravate interstitial pneumonia and acute respiratory distress syndrome (ARDS) [3][4][5][6]. This clinical picture evolves into viral sepsis with prominent hypercoagulability and multiorgan dysfunction [7][8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Autopsy findings in COVID-19-related deaths: a literature review

Maiese

Manetti

Russa

et al. 2020

Forensic Sci Med Pathol

170

162

View full text Add to dashboard Cite

Although many clinical reports have been published, little is known about the pathological post-mortem findings from people who have died of the novel coronavirus disease. The need for postmortem information is urgent to improve patient management of mild and severe illness, and treatment strategies. The present systematic review was carried out according to the Preferred Reporting Items for Systematic Review (PRISMA) standards. A systematic literature search and a critical review of the collected studies were conducted. An electronic search of PubMed, Science Direct Scopus, Google Scholar, and Excerpta Medica Database (EMBASE) from database inception to June 2020 was performed. We found 28 scientific papers; the total amount of cases is 341. The major histological feature in the lung is diffuse alveolar damage with hyaline membrane formation, alongside microthrombi in small pulmonary vessels. It appears that there is a high incidence of deep vein thrombosis and pulmonary embolism among COVID-19 decedents, suggesting endothelial involvement, but more studies are needed. A uniform COVID-19 post-mortem diagnostic protocol has not yet been developed. In a time in which international collaboration is essential, standardized diagnostic criteria are fundamental requirements.

show abstract

COVID-19, de novo seizures, and epilepsy: a systematic review

et al. 2020

View full text Add to dashboard Cite

Objective We discuss the evidence on the occurrence of de novo seizures in patients with COVID-19, the consequences of this catastrophic disease in people with epilepsy (PWE), and the electroencephalographic (EEG) findings in patients with COVID-19. Methods This systematic review was prepared according to the recommendations of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. MEDLINE, Scopus, and Embase from inception to August 15, 2020 were systematically searched. These key words were used: "COVID" AND "seizure" OR "epilepsy" OR "EEG" OR "status epilepticus" OR "electroencephalography". Results We could identify 62 related manuscripts. Many studies were case reports or case series of patients with COVID-19 and seizures. PWE showed more psychological distress than healthy controls. Many cases with new-onset focal seizures, serial seizures, and status epilepticus have been reported in the literature. EEG studies have been significantly ignored and underused globally. Conclusion Many PWE perceived significant disruption in the quality of care to them, and some people reported increase in their seizure frequency since the onset of the pandemic. Telemedicine is a helpful technology that may improve access to the needed care for PWE in these difficult times. De novo seizures may occur in people with COVID-19 and they may happen in a variety of forms. In addition to prolonged EEG monitoring, performing a through metabolic investigation, electrocardiogram, brain imaging, and a careful review of all medications are necessary steps. The susceptibility of PWE to contracting COVID-19 should be investigated further.

show abstract

Multi-Organ Failure in a Patient With Diabetes due to COVID-19 With Clear Lungs

Cited by 14 publications

References 6 publications

Clinical profile and outcomes in COVID-19 patients with diabetic ketoacidosis: A systematic review of literature

Clinical profile and outcomes in COVID-19 patients with diabetic ketoacidosis: A systematic review of literature

Autopsy findings in COVID-19-related deaths: a literature review

COVID-19, de novo seizures, and epilepsy: a systematic review

Contact Info

Product

Resources

About