Multi-omics reveals the protective effects of curcumin against AFB1-induced oxidative stress and inflammatory damage in duckling intestines

Jiang, Xuanxuan; Liu, Haiyan; You, Yanli; Zhong, Gaolong; Ruan, Zhiyan; Liao, Jianzhao; Zhang, Hui; Pan, Jiaqiang; Tang, Zhaoxin; Hu, Lianmei

doi:10.1016/j.cbpc.2023.109815

Cited by 2 publications

(2 citation statements)

References 68 publications

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“…In addition, the metabolites and free radicals produced during autometabolism may also cause damage to intestinal cells, leading to the occurrence of oxidative stress. Oxidative stress causes an imbalance in the redox balance within cells, increases the production of free radicals, and leads to the lipid peroxidation of cell membranes, the oxidation of proteins, and damage to DNA [ 112 , 113 ]. The damage of ROS to the intestine is affected by a variety of factors, such as the amount of free radicals and the antioxidant capacity of the body.…”

Section: Unconventional Fermented Feed Improves Oxidative Stress By R...mentioning

confidence: 99%

The Effects of Unconventional Feed Fermentation on Intestinal Oxidative Stress in Animals

Lian,

Shi,

Liang

et al. 2024

Antioxidants

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Unconventional feed, which is abundant in China, contains anti-nutritional factors and toxins; however, these can be greatly reduced with microbial fermentation, thus improving the nutrient content of the feed, enhancing animal appetites, and ultimately significantly improving the intestinal health and growth performance of animals. When oxidative stress occurs, fermented feed can effectively reduce the damage caused by stress to the gastrointestinal tract, accelerate the removal of gastrointestinal abnormalities, improve the ability to resist intestinal stress, and ensure the efficient production of animals. This review introduces the application of unconventional fermented feed in animal production, and expounds upon the function of unconventional fermented feed in animals with oxidative stress symptoms, so as to provide a theoretical reference for the development and application of unconventional fermented feed in antioxidative stress reduction.

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Section: Unconventional Fermented Feed Improves Oxidative Stress By R...mentioning

confidence: 99%

The Effects of Unconventional Feed Fermentation on Intestinal Oxidative Stress in Animals

Lian,

Shi,

Liang

et al. 2024

Antioxidants

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“…Perillic acid, a major metabolite of D-limonene, regulates the body immune response by increasing the total numbers of white blood cells and promotes the production of the antioxidative compound glutathione in the small intestine of mice [ 13 , 14 , 15 ]. Curcumin protected against oxidative injury and inflammation of the gut through inhibiting the nuclear factor κ-B (NF-κB)/IκB signaling pathway, decreasing m6A RNA methylation and boosting intestinal autophagy in duckling and piglet models [ 16 , 17 , 18 ]. In addition, the phenolic compounds cinnamic acid and chlorogenic acid have been proposed to have antioxidant and anti-inflammatory properties [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Cinnamic Acid, Perillic Acid, and Tryptophan Metabolites Differentially Regulate Ion Transport and Serotonin Metabolism and Signaling in the Mouse Ileum In Vitro

Jiang,

Hao,

et al. 2024

IJMS

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Phytochemicals and tryptophan (Trp) metabolites have been found to modulate gut function and health. However, whether these metabolites modulate gut ion transport and serotonin (5-HT) metabolism and signaling requires further investigation. The aim of this study was to investigate the effects of selected phytochemicals and Trp metabolites on the ion transport and 5-HT metabolism and signaling in the ileum of mice in vitro using the Ussing chamber technique. During the in vitro incubation, vanillylmandelic acid (VMA) reduced (p < 0.05) the short-circuit current, and 100 μM chlorogenic acid (CGA) (p = 0.12) and perillic acid (PA) (p = 0.14) had a tendency to reduce the short-circuit current of the ileum. Compared with the control, PA and N-acetylserotonin treatment upregulated the expression of tryptophan hydroxylase 1 (Tph1), while 100 μM cinnamic acid, indolelactic acid (ILA), and 10 μM CGA or indoleacetaldehyde (IAld) treatments downregulated (p < 0.05) the mRNA levels of Tph1. In addition, 10 μM IAld or 100 μM ILA upregulated (p < 0.05) the expression of monoamine oxidase A (Maoa). However, 10 μM CGA or 100 μM PA downregulated (p < 0.05) Maoa expression. All selected phytochemicals and Trp metabolites upregulated (p < 0.05) the expression of Htr4 and Htr7 compared to that of the control group. VMA and CGA reduced (p < 0.05) the ratios of Htr1a/Htr7 and Htr4/Htr7. These findings may help to elucidate the effects of phytochemicals and Trp metabolites on the regulation of gut ion transport and 5-HT signaling-related gut homeostasis in health and disease.

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Multi-omics reveals the protective effects of curcumin against AFB1-induced oxidative stress and inflammatory damage in duckling intestines

Cited by 2 publications

References 68 publications

The Effects of Unconventional Feed Fermentation on Intestinal Oxidative Stress in Animals

The Effects of Unconventional Feed Fermentation on Intestinal Oxidative Stress in Animals

Cinnamic Acid, Perillic Acid, and Tryptophan Metabolites Differentially Regulate Ion Transport and Serotonin Metabolism and Signaling in the Mouse Ileum In Vitro

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