Multi-omics Reveals Immune Response and Metabolic Profiles during High-Altitude Mountaineering
Jianhua Yin,
Jingzhi Lv,
Shichen Yang
et al.
Abstract:SUMMARYThe physiological perturbations induced by high-altitude exposure in mountain climbers, manifesting as metabolic and immunologic deviations, have been previously reported but are not fully understood. In this study, we obtained longitudinal multi-omic profiles of blood samples for healthy mountain climbers during two mountaineering stages (acclimatization and extreme altitude mountaineering). Our integrative assay included metabolomics and lipidomics profiling of plasma coupled with single-cell transcri… Show more
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