Multi-omics profiling reveals phenotypic and functional heterogeneity of neutrophils in COVID-19
Lin Zhang,
Hafumi Nishi,
Kengo Kinoshita
Abstract:Background: Accumulating evidence has revealed unexpected phenotypic heterogeneity and diverse functions of neutrophils in several diseases. Coronavirus disease (COVID-19) can alter the leukocyte phenotype based on disease severity, including neutrophil activation in severe cases. However, the plasticity of neutrophil phenotypes and their relative impact on COVID-19 pathogenesis has not been well addressed. This study aimed to identify and validate the heterogeneity of neutrophils in COVID-19 and evaluate the … Show more
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