Multi-omics insight into the metabolic and cellular characteristics in the pathogenesis of hypothyroidism
Shengzhang Zheng,
Lihua Liu,
Kailin Liang
et al.
Abstract:While circulating metabolites and immune system have been increasingly linked to hypothyroidism risk, the causality underlying these associations remains largely uninterrogated. We used Mendelian randomization to identified putative causal traits for hypothyroidism via integrating omics data. Briefly, we utilized 1180 plasma metabolites and 731 immune cells traits as exposures to identify putatively causal traits for hypothyroidism in the discovery (40,926 cases) and replication cohorts (14,871 cases). By comb… Show more
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