Abstract:A systematic method was proposed to infer differential gene regulatory networks (GRNs) among lung adenocarcinoma (LUAD) samples at different stages by integrating multi‐omics data to uncover significant network features and to identify tumor progression (TP) biomarker genes. The mRNA expressions, copy number variations, and DNA methylations of two independent LUAD cohorts (TCGA and SPORE) at stages I, II, and III were used, respectively. As results, the transition from normal to early onset was showed to be cr… Show more
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