Multi-omics approaches for deciphering the complexity of traditional Chinese medicine syndromes in stroke: A systematic review

Liu, Tingting; Qin, Mingzhen; Xiong, Xuejiao; Lai, Xinxing; Gao, Ying

doi:10.3389/fphar.2022.980650

Cited by 7 publications

(5 citation statements)

References 32 publications

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“…A large number of studies show that the buyang huanwu soup, ginseng injection, ginseng wheat injection, ginseng pine nourishing heart capsule, ginseng dome glucose injection, etc. are effective for the treatment of brain-heart syndrome ( Li et al, 2016 ; Liu et al, 2016 ; Yang et al, 2016 ; Ji, 2020 ; Sun et al, 2022 ), and acupuncture from traditional medicine also has a positive effect on brain-heart syndrome ( Ya-jun et al, 2020 ; Liu et al, 2022 ). It has been shown that Edaravone is a novel free radical scavenger and antioxidant that is highly effective against a variety of acute cerebrovascular diseases and protects the cardiomyocytes of stroke patients ( Jiang et al, 2016 ).…”

Section: Advances In the Treatment Of Stroke-heart Syndromementioning

confidence: 99%

Advances in brain-heart syndrome: Attention to cardiac complications after ischemic stroke

Wang

Peng²

2022

Front. Mol. Neurosci.

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Neurocardiology is an emerging field that studies the interaction between the brain and the heart, namely the effects of heart injury on the brain and the effects of brain damage on the heart. Acute ischemic stroke has long been known to induce heart damage. Most post-stroke deaths are attributed to nerve damage, and cardiac complications are the second leading cause of death after stroke. In clinical practice, the proper interpretation and optimal treatment for the patients with heart injury complicated by acute ischemic stroke, recently described as stroke-heart syndrome (SHS), are still unclear. Here, We describe a wide range of clinical features and potential mechanisms of cardiac complications after ischemic stroke. Autonomic dysfunction, microvascular dysfunction and coronary ischemia process are interdependent and play an important role in the process of cardiac complications caused by stroke. As a unique comprehensive view, SHS can provide theoretical basis for research and clinical diagnosis and treatment.

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Section: Advances In the Treatment Of Stroke-heart Syndromementioning

confidence: 99%

Advances in brain-heart syndrome: Attention to cardiac complications after ischemic stroke

Wang

Peng²

2022

Front. Mol. Neurosci.

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“…TCM pattern differentiation is the cornerstone for TCM practitioners to understand diseases and guide individualized clinical medication. However, TCM pattern differentiation has a certain degree of complexity, ambiguity, and subjectivity ( 20 ). Firstly, the syndrome description of TCM patterns is based on human patients, which is difficult to transfer to animal models for simulation or experiment.…”

Section: Discussionmentioning

confidence: 99%

Differentiation in TCM patterns of chronic obstructive pulmonary disease by comprehensive metabolomic and lipidomic characterization

Liu

Shi

et al. 2023

Front. Immunol.

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IntroductionChronic obstructive pulmonary disease (COPD) is a complex disease involving inflammation, cell senescence, and autoimmunity. Dialectical treatment for COPD with traditional Chinese medicine (TCM) has the advantage of fewer side effects, more effective suppression of inflammation, and improved immune function. However, the biological base of TCM pattern differentiation in COPD remains unclear.MethodsLiquid Chromatography-Quadrupole-Orbitrap mass spectrometry (LC-Q-Orbitrap MS/MS) based metabolomics and lipidomics were used to analyze the serum samples from COPD patients of three TCM patterns in Lung Qi Deficiency (n=65), Lung-Kidney Qi Deficiency (n=54), Lung-Spleen Qi Deficiency (n=52), and healthy subjects (n=41). Three cross-comparisons were performed to characterize metabolic markers for different TCM patterns of COPD vs healthy subjects.ResultsWe identified 28, 8, and 16 metabolites with differential abundance between three TCM patterns of COPD vs healthy subjects, respectively, the metabolic markers included cortisol, hypoxanthine, fatty acids, alkyl-/alkenyl-substituted phosphatidylethanolamine, and phosphatidylcholine, etc. Three panels of metabolic biomarkers specific to the above three TCM patterns yielded areas under the receiver operating characteristic curve of 0.992, 0.881, and 0.928, respectively, with sensitivity of 97.1%, 88.6%, and 91.4%, respectively, and specificity of 96.4%, 81.8%, and 83.9%, respectively.DiscussionCombining metabolomics and lipidomics can more comprehensively and accurately trace metabolic markers. As a result, the differences in metabolism were proven to underlie different TCM patterns of COPD, which provided evidence to aid our understanding of the biological basis of dialectical treatment, and can also serve as biomarkers for more accurate diagnosis.

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“…Multi-omics research is crucial for understanding the biological basis of Chinese medicine symptoms and providing molecular evidence for the creation of new Chinese medicine therapeutic medicines. A recent systematic review has summarized core factors of multi-omics data associated with Chinese medicine stroke syndromes, and has indicated that thioredoxin-dependent peroxidase reductase and mRNAs targeted by some microRNAs (miR-146b-5p, -199a-5p, and 23) are responsible for liver-Yang transforming into wind syndrome and blood-stasis syndrome, respectively [100]. Additionally, network pharmacology can be used to analyze and integrate data from various omics platforms to identify potential therapeutic targets and drug candidates.…”

Section: Integrative Omicsmentioning

confidence: 99%

Multi-component Chinese medicine formulas for drug discovery: State of the art and future perspectives

Zhang

Chen

Tang

et al. 2023

Acta Materia Medica

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For hundreds of years, the drug discovery and development industry has aimed at identifying single components with a clear mechanism of action as desirable candidates for potential drugs. However, this conventional strategy of drug discovery and development has faced challenges including a low success rate and high development costs. Herein, we critically review state-of-the-art drug discovery and development based on multi-component Chinese medicine formulas. We review the policies and application status of new drugs based on multi-component Chinese medicines in the US, China, and the European Union. Moreover, we illustrate several excellent cases of ongoing applications. Biomedical technologies that may facilitate drug discovery and development based on multi-component Chinese medicine formulas are discussed, including network pharmacology, integrative omics, CRISPR gene editing, and chemometrics. Finally, we discuss potential problems and solutions in pre-clinical and clinical research in drug discovery and development based on multi-component Chinese medicine formulas. We hope that this review will promote discussion of the roles of multi-component Chinese medicine formulas in the discovery and development of new drugs for the treatment of human diseases.

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Multi-omics approaches for deciphering the complexity of traditional Chinese medicine syndromes in stroke: A systematic review

Cited by 7 publications

References 32 publications

Advances in brain-heart syndrome: Attention to cardiac complications after ischemic stroke

Advances in brain-heart syndrome: Attention to cardiac complications after ischemic stroke

Differentiation in TCM patterns of chronic obstructive pulmonary disease by comprehensive metabolomic and lipidomic characterization

Multi-component Chinese medicine formulas for drug discovery: State of the art and future perspectives

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