Multi-omics analysis unravels positive effect of rotenone on the cordycepin biosynthesis in submerged fermentation of Cordyceps militaris

Ma, You-Chu; Huang, Ping; Wang, Xiaoling; Liu, Gao-Qiang

doi:10.1016/j.biortech.2023.128705

Cited by 6 publications

(2 citation statements)

References 30 publications

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“…The addition of 5 mg/L rotenone significantly increased cordycepin production by 316.09%, along with mycelial growth inhibition and cell wall destruction. The integrated analysis of the two omics confirmed that rotenone altered the nucleosides metabolism pathway toward adenosine and activated the genes responsible for producing cordycepin ( cns1-3 ) from adenosine ( Ma et al, 2023 ). The L-alanine addition to C. militaris fermentation increased cordycepin yield by up-regulating the transcriptome level of genes involved in the bio-pathways of energy generation and amino acid conversion.…”

Section: Biosynthesis Pathways Of Cordycepinmentioning

confidence: 80%

“…Metabolomics studies showed that many metabolic pathways have been changed in the high-yielding cordycepin strains, e.g., citric acid cycle, purine metabolism, and pyrimidine metabolism ( Ma et al, 2023 ). Changes in polysaccharide and protein synthesis metabolic poly-pathways, such as galactose metabolism and amino acid metabolism, would boost cordycepin′s production ( Yu et al, 2023 ).…”

Section: Biosynthesis Pathways Of Cordycepinmentioning

confidence: 99%

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Advances in biosynthesis and metabolic engineering strategies of cordycepin

Peng,

Guo,

Tong

2024

Front. Microbiol.

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Cordyceps militaris, also called as bei-chong-cao, is an insect-pathogenic fungus from the Ascomycota phylum and the Clavicipitaceae family. It is a valuable filamentous fungus with medicinal and edible properties that has been utilized in traditional Chinese medicine (TCM) and as a nutritious food. Cordycepin is the bioactive compound firstly isolated from C. militaris and has a variety of nutraceutical and health-promoting properties, making it widely employed in nutraceutical and pharmaceutical fields. Due to the low composition and paucity of wild resources, its availability from natural sources is limited. With the elucidation of the cordycepin biosynthetic pathway and the advent of synthetic biology, a green cordycepin biosynthesis in Saccharomyces cerevisiae and Metarhizium robertsii has been developed, indicating a potential sustainable production method of cordycepin. Given that, this review primarily focused on the metabolic engineering and heterologous biosynthesis strategies of cordycepin.

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Section: Biosynthesis Pathways Of Cordycepinmentioning

confidence: 80%

Section: Biosynthesis Pathways Of Cordycepinmentioning

confidence: 99%