Multi-omics analysis reveals changes in tryptophan and cholesterol metabolism before and after sexual maturation in captive macaques

Liu, Xu; Liu, Xuyuan; Wang, Xinqi; Shang, Ke; Li, Jiawei; Lan, Yue; Wang, Jiao; Li, Jing; Yue, Bisong; He, Miao; Fan, Zhenxin

doi:10.1186/s12864-023-09404-3

Cited by 1 publication

(1 citation statement)

References 93 publications

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“…In a fish model, tryptophan feeding resulted in an upregulation of fatty acid biosynthesis, protein digestive absorption, and protein phosphatase I. Conversely, tryptophan was related to the downregulation of phosphofructokinase-2/fructose-2,6-bisphosphatase 3 [ 57 , 58 ]. In macaques, subjects with higher tryptophan levels showed increasing fatty acid biosynthesis, pyruvate fermentation, and glycosyl transferase activity [ 59 ]. Our study showed different outcomes regarding protein and carbohydrate metabolism based on varying tryptophan concentrations, though it may not be reasonable to compare the gut microbiota and its functions in different animals.…”

Section: Discussionmentioning

confidence: 99%

Identification of Gut Microbiome Signatures Associated with Indole Pathway in Tryptophan Metabolism in Patients Undergoing Hemodialysis

Huang,

Wu,

Chen

et al. 2024

Biomolecules

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Microbiota tryptophan metabolism and the biosynthesis of indole derivatives play an important role in homeostasis and pathogenesis in the human body and can be affected by the gut microbiota. However, studies on the interplay between gut microbiota and tryptophan metabolites in patients undergoing dialysis are lacking. This study aimed to identify the gut microbiota, the indole pathway in tryptophan metabolism, and significant functional differences in ESRD patients with regular hemodialysis. We performed the shotgun metagenome sequencing of stool samples from 85 hemodialysis patients. Using the linear discriminant analysis effect size (LEfSe), we examined the composition of the gut microbiota and metabolic features across varying concentrations of tryptophan and indole metabolites. Higher tryptophan levels promoted tyrosine degradation I and pectin degradation I metabolic modules; lower tryptophan levels were associated with glutamate degradation I, fructose degradation, and valine degradation modules. Higher 3-indoxyl sulfate concentrations were characterized by alanine degradation I, anaerobic fatty acid beta-oxidation, sulfate reduction, and acetyl-CoA to crotonyl-CoA. Contrarily, lower 3-indoxyl sulfate levels were related to propionate production III, arabinoxylan degradation, the Entner–Doudoroff pathway, and glutamate degradation II. The present study provides a better understanding of the interaction between tryptophan, indole metabolites, and the gut microbiota as well as their gut metabolic modules in ESRD patients with regular hemodialysis.

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Section: Discussionmentioning

confidence: 99%