Multi-omics analysis of human gut microbiota in colorectal cancer patients

Abstract

Colorectal cancer (CRC) is a critical health problem. It is the second cause of death globally and the third world's most frequently diagnosed. Multiple evidences and suggestion imply the relationship of gut microbiota and colorectal cancer carcinogenesis. The different omics techniques like, metagenomic, metaproteomic and metabolomic approaches have led to important advances in the study of the intestinal microbiome, the host as well as the intestinal environment. Different bacterial species, proteins and metabolites have a crucial role in colorectal cancer screening, detection and recurrence. Integration of these three omics analysis in drawing attention to reveal taxonomic and functional structure of human gut microbiota in addition several protein and metabolites detection had helped in construction of microbial communities and their diversity in colorectal cancer patients and healthy controls besides that these bacterial species, metabolites and proteins could be used as a critical biomarkers candidate in colorectal cancer detection, prognosis and recurrence.