Multi-omic profiling of breast tumor microenvironment uncovers a role of mitochondrial calcium gatekeepers
Yen-Dun Tony Tzeng,
Pei-Yi Chu,
Su-Boon Yong
et al.
Abstract:In this study, we aimed to elucidate the role of mitochondrial calcium uptake 1/2 (MiCU1/2) in breast cancer (BRCA) by employing a comprehensive multi-omics approach. Unlike previous research, we utilized a novel web application tailored for whole tumor tissue, single-cell, and spatial transcriptomics analysis to investigate the association between MiCU1/2 and the tumor immune microenvironment (TIME). Our gene set enrichment analysis (GSEA) provided insights into the primary biological effects of MiCU1/2, whil… Show more
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