Multi-omic characterization of antibody-producing CHO cell lines elucidates metabolic reprogramming and nutrient uptake bottlenecks
Saratram Gopalakrishnan,
William Johnson,
Miguel A. Valderrama-Gomez
et al.
Abstract:Characterizing the phenotypic diversity and metabolic capabilities of industrially relevant manufacturing cell lines is critical to bioprocess optimization and cell line development. Metabolic capabilities of the production hosts limit nutrient and resource channeling into desired cellular processes and can have a profound impact on productivity but cannot be directly inferred from measured data such as spent media concentrations or transcriptomics. Here, we present an integrated multi-omic characterization ap… Show more
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