To improve the water application uniformity for sprinkler irrigation on sloping land, a new type of pressure-regulating device was designed. The pressure regulation device was installed between the pipe and the inlet of the sprinkler to regulate the pressure gradient. In this study, PIPENET software was used to simulate the installation of pressure regulation device on the corresponding PY10 sprinklers and analyze the working modes of each sprinkler in the irrigation system. The simulation considered factors such as sprinkler combination layout, ground slope and sprinkler interval distance, with average application rate and uniformity coefficient as evaluation criteria. The results showed that the installation of pressure regulation device reduced the pressure difference between each sprinkler. Under these conditions, irrigation uniformity was improved. The research results indicate that integrating different sprinkler layouts, ground slopes and sprinkler interval distances significantly improved the effectiveness of pressure-regulating device installation in hilly areas. This study provided a reference for addressing poor irrigation uniformity in sloping land in hilly areas.