Multi-mode biodegradable tumour-microenvironment sensitive nanoparticles for targeted breast cancer imaging

Abstract

Gas-filled ultrasound (US) contrast agents easily collapse in the body, and the gas can easily overflow, which limits the effectiveness of US imaging. To address this issue, an injectable gas-generating multi-mode system was developed that carries the MR negative contrast agent Fe 3 O 4 , the fluorescent dye Cy5.5, and the CO 2 releasing donor (Na 2 CO 3 ). The nanoparticles can continuously generate carbon dioxide (CO 2 ) gas in acidic tumour tissue in the body, giving the tumour a strong echo signal under ultrasonic imaging. In addition, the nanoparticles confer excellent effects for MR and fluorescence imaging of the tumour tissue. The results indicate that this pH-responsive NP system provides good effects in MR/US/fluorescent imaging. This study provides a useful reference for multimode tumour imaging.

Low-intensity pulsed ultrasound/nanomechanical force generators enhance osteogenesis of BMSCs through microfilaments and TRPM7

“…Ordinary lipid microbubbles still have some limitations in practical applications, due to their large size, low stability, and poor vascular penetration ability [ 26 ]. With the rapid development of nanotechnology, nanoscale lipid bubbles (nanobubbles) encapsulated in phospholipid shells exhibit high stability, good biosafety, and vascular penetration ability [ 27 , 28 ].…”

Multifunctional self-assembled peptide nanoparticles for multimodal imaging-guided enhanced theranostic applications against glioblastoma multiforme

“…Next, the deprotected amino group of the central lysine residue of the cPD complex was covalently conjugated with Cy5.5 during the self-assembly process, as illustrated in StepII(a) of Scheme 1. 32 The co-assembly of Cy5.5 with the cPD complex was successfully achieved to yield uniform size self-assembled peptide nanoparticles (Cy5.5@SAPD) with a well-dened spherical shape and "always ON" NIR-uorescence properties by using the pH-sensitive method. 29,33 This will facilitate in improving the diagnostic and therapeutic efficiencies of dual-targeting dual-imaging Cy5.5@SAPD nanoparticles, whilst maintaining the intrinsic biocompatibility and biodegradability.…”

Advances in nanomedicines for lymphatic imaging and therapy

“…The preparation material of nano-bubbles mainly consists of a double-layered shell of perfluorocarbon nanodroplets or albumin and an inner layer of a biodegradable polymer called polyethylene glycol. This shell-core structure can effectively encapsulate gases such as nitrogen for tracking using ultrasound imaging techniques [ 122 , 123 ]. During the ultrasound imaging process, since nano-bubbles can rupture and form smaller bubbles, some have suggested using nano-bubbles to carry therapeutic drugs and injecting them into cells through the explosion of the nano-bubbles to achieve drug delivery and controlled release in lymph nodes.…”