Multi-modal stabilisation of emulsions using a combination of hydrophilic particles and an amino acid

Marina, Paula Facal; Delcheva, Iliana; Beattie, David A.

doi:10.1016/j.colsurfa.2017.11.074

Cited by 5 publications

(2 citation statements)

References 38 publications

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“…Results from SEM, FA, CLSM, and DSC all supported the conclusion that puerarin nanocrystals were adsorbed onto the surface of oil droplets in Pu-NSSPE. It was reported that when 30° < θ < 150°, the energy required for detaching the particles from the oil-water interface would be several orders larger than the kinetic energy for Brownian motion [39]. Therefore, θ of 81 ± 4° could make the adsorption of puerarin nanocrystals at the oil-water interface irreversible.…”

Section: Resultsmentioning

confidence: 99%

Development of an Oral Compound Pickering Emulsion Composed of Nanocrystals of Poorly Soluble Ingredient and Volatile Oils from Traditional Chinese Medicine

Zhang

Wang

et al. 2018

Pharmaceutics

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In this study, an oral drug nanocrystals self-stabilized Pickering emulsion (NSSPE), which used nanocrystals of a poorly soluble ingredient from Puerariae Radix called puerarin as solid particle stabilizers and Ligusticum chuanxiong essential oil since the main oil phase had been developed to improve the oral bioavailability of puerarin. The appearance of emulsions, size and zeta potential of droplets, and content of puerarin in emulsified layer during a storage of six months at 4, 25, and 40 °C were investigated. The centrifugation stability at 4000× g was also studied. The micro-structure of emulsion droplets was characterized by a scanning electron micrograph (SEM), confocal laser scanning microscopy (CLSM), a fluorescence microscope (FM), and differential scanning calorimetry (DSC). The in vivo oral bioavailability of puerarin NSSPE was investigated in rats. Results showed that appearances of puerarin NSSPE kept stable after centrifugation at 4000× g for 15 min or storage for six months at 4, 25, and 40 °C. SEM, CLSM, FM, and DSC showed that the puerarin NSSPE had a stable core-shell structure of emulsion droplets formed by the adsorption of puerarin nanocrystals on the surface of oil droplets of mixed oil of Ligusticum chuanxiong essential oil and Labrafil M 1944 CS (9:1, v/v). The relative bioavailability of puerarin NSSPE to puerarin coarse powder suspension, nanocrystal suspension, and surfactant emulsion were 262.43%, 155.92%, and 223.65%, respectively. All these results indicated that puerarin nanocrystals could stabilize Pickering emulsion of Ligusticum chuanxiong essential oil without any other stabilizers and Pickering emulsion could improve the oral bioavailability of puerarin, which suggests that the drug nanocrystal self-stabilized Pickering emulsion as a promising oral drug delivery system for Traditional Chinese Medicine containing poorly soluble ingredients and volatile oils.

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Section: Resultsmentioning

confidence: 99%

Development of an Oral Compound Pickering Emulsion Composed of Nanocrystals of Poorly Soluble Ingredient and Volatile Oils from Traditional Chinese Medicine

Zhang

Wang

et al. 2018

Pharmaceutics

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show abstract

“…Indeed, the latest trends point towards the use of types of particle as yet unexplored, such as coloured organic pigment, core–shell, polymeric and highly hydrophilic particles. 33 – 37 With regards to the latter, several attempts have been made to use hydrophilic silica particles to stabilize oil-in-water emulsions by either adjusting the solution pH, adding salt, adding a cationic surfactant or even by in situ modification of the particles’ surface. 38 – 40 It seems reasonable that decreasing the effective anionic surface charge density on the silica particles causes the particles to be less hydrophilic.…”

Section: Introductionmentioning

confidence: 99%

Thinking outside the box: placing hydrophilic particles in an oil phase for the formation and stabilization of Pickering emulsions

Marina

et al. 2018

Chem. Sci.

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The pH dependent surface charging and points of zero charge. VIII. Update

Kosmulski

2020

Advances in Colloid and Interface Science

119

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Multi-modal stabilisation of emulsions using a combination of hydrophilic particles and an amino acid

Cited by 5 publications

References 38 publications

Development of an Oral Compound Pickering Emulsion Composed of Nanocrystals of Poorly Soluble Ingredient and Volatile Oils from Traditional Chinese Medicine

Development of an Oral Compound Pickering Emulsion Composed of Nanocrystals of Poorly Soluble Ingredient and Volatile Oils from Traditional Chinese Medicine

Thinking outside the box: placing hydrophilic particles in an oil phase for the formation and stabilization of Pickering emulsions

The pH dependent surface charging and points of zero charge. VIII. Update

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