Multi‐modal induction and assessment of allodynia and hyperalgesia in the human oesophagus

Drewes, Asbjørn Mohr; Schipper, Klaus-Peter; Petersen, P.; Andersen, Ole Kæseler; Gregersen, Hans; Arendt‐Nielsen, Lars

doi:10.1016/s1090-3801(03)00053-3

Cited by 96 publications

(114 citation statements)

References 50 publications

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“…Administration of capsaicin by itself or in a combination with acid has been shown to induce visceral hyperalgesia, which has led to hypersensitivity to heat and mechanical, electrical, and chemical stimulation (Gonzalez et al, 1998;Drewes et al, 2003a;Lee et al, 2004;Hammer, 2006;Hammer and Vogelsang, 2007;Olesen et al, 2009;Brock et al, 2010). These stimuli are likely to reflect both peripheral and central sensitization.…”

Section: Intraesophageal Capsaicin Installationmentioning

confidence: 99%

Unravelling the Mystery of Capsaicin: A Tool to Understand and Treat Pain

O’Neill

Brock²,

Olesen³

et al. 2012

Pharmacol Rev

272

231

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Section: Intraesophageal Capsaicin Installationmentioning

confidence: 99%

Unravelling the Mystery of Capsaicin: A Tool to Understand and Treat Pain

O’Neill

Brock²,

Olesen³

et al. 2012

Pharmacol Rev

272

231

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“…Visceral hyperalgesia has been induced by, for example, acid, capsaicin, and glycerol (Drewes et al, 2003b;Hammer and Vogelsang, 2007;van den Elzen et al, 2009). Acid perfusion of the esophagus is the most widely used chemical stimulus inducing both peripheral and central sensitization as generalized hyperalgesia (Sarkar et al, 2001;Drewes et al, 2003a).…”

Section: Visceramentioning

confidence: 99%

“…Most of the studies on visceral hyperalgesia have demonstrated increased pain in response to one or more modalities after experimentally induced sensitization by chemicals (Sarkar et al, 2001(Sarkar et al, , 2003Drewes et al, 2003a;Hobson et al, 2004;Pedersen et al, 2004;Frøkjaer et al, 2005;Sami et al, 2006;Willert et al, 2007;Brock et al, 2009a).…”

Section: Visceramentioning

confidence: 99%

Human Experimental Pain Models for Assessing the Therapeutic Efficacy of Analgesic Drugs

et al. 2012

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“…The majority of human studies elucidating visceral pain and/or hypersensitivity in patients with NCCP have used balloon distension in the esophagus and evaluated esophageal pain by scoring pain perception and/or by imaging cortical brain activity in response to different esophageal stimuli. Repeated esophageal balloon distensions and acid exposures decrease the pain threshold in response to the mechanical stimulus of esophagus in patients with NCCP (10,12,20,29,(45)(46)(47). However, one study contradicted this result (8).…”

mentioning

confidence: 99%

Intraesophageal chemicals enhance responsiveness of upper thoracic spinal neurons to mechanical stimulation of esophagus in rats

Qin

Farber²,

Foreman³

2008

American Journal of Physiology-Gastrointestinal and Liver Physi

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Qin C, Farber JP, Foreman RD. Intraesophageal chemicals enhance responsiveness of upper thoracic spinal neurons to mechanical stimulation of esophagus in rats. Am J Physiol Gastrointest Liver Physiol 294: G708-G716, 2008. First published January 10, 2008 doi:10.1152/ajpgi.00477.2007.-Esophageal hypersensitivity is one of the most common causes of noncardiac chest pain in patients. In this study, we investigated whether exposure of the esophagus to acid and other chemical irritants affected activity of thoracic spinal neurons responding to esophageal distension (ED) in rats. Extracellular potentials of single thoracic (T3) spinal neurons were recorded in pentobarbital sodium-anesthetized, -paralyzed, and -ventilated male rats. ED (0.2 or 0.4 ml, 20 s) was produced by water inflation of a latex balloon placed orally into the middle thoracic region of the esophagus. The chemicals were administered via a tube that was passed through the stomach and placed in the thoracic esophagus. To irritate the esophagus, 0.2 ml of HCl (0.01 N), bradykinin (10 g/ml), or capsaicin (10 g/ml) were injected for 1-2 min. Only neurons excited by ED were included in this study. Results showed that intraesophageal instillation of HCl, bradykinin, and capsaicin increased activity in 3/20 (15%), 7/25 (28%), and 9/20 (45%) neurons but enhanced excitatory responses to ED in 9/17 (53%), 8/15 (53%), and 7/11 (64%) of the remaining spinal neurons, respectively. Furthermore, intraesophageal chemicals were more likely to enhance the responsiveness of low-threshold neurons than high-threshold neurons to the esophageal mechanical stimulus. Normal saline (pH 7.4, 0.2 ml) or vehicle instilled in the esophagus did not significantly affect activity or ED responses of neurons. We conclude that enhanced responses of thoracic spinal neurons to ED by the chemically challenged esophagus may provide a possible pathophysiological basis for visceral hypersensitivity in patients with gastroesophageal reflux and/or esophagitis. visceral hypersensitivity; gastroesophageal reflux; noncardiac chest pain; esophagitis; heartburn ESOPHAGEAL PAIN AND/OR HYPERSENSITIVITY is one of the most common causes of noncardiac chest pain (NCCP). About 60% of such patients have gastroesophageal reflux disease (GERD). The typical symptoms of GERD are heartburn and/or acid regurgitation arising from the reflux of gastric acid. Surveys of the U.S. population suggest that 7-10% of adults experience these symptoms daily (21,23,24,31). Therefore, ϳ19 million people per year have to live with GERD, and as a result they experience a reduced quality of life. Among the various gastrointestinal diseases in the U.S. population, GERD creates the highest financial burden with the highest annual direct costs ($9.3 billion U.S. dollars) (44). Some patients with GERD have chronic complications such as various laryngeal and pulmonary disorders (22) and may develop esophagitis, Barrett's esophagus (precancerous lesion), or esophageal adenocarcinoma (5, 55). Despite the prevalence and clinical signi...

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Multi‐modal induction and assessment of allodynia and hyperalgesia in the human oesophagus

Cited by 96 publications

References 50 publications

Unravelling the Mystery of Capsaicin: A Tool to Understand and Treat Pain

Unravelling the Mystery of Capsaicin: A Tool to Understand and Treat Pain

Human Experimental Pain Models for Assessing the Therapeutic Efficacy of Analgesic Drugs

Intraesophageal chemicals enhance responsiveness of upper thoracic spinal neurons to mechanical stimulation of esophagus in rats

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