Multi-modal brain magnetic resonance imaging database covering marmosets with a wide age range

Abstract

Magnetic resonance imaging (MRI) is a non-invasive neuroimaging technique that is useful for identifying normal developmental and aging processes and for data sharing. Marmosets have a relatively shorter life expectancy than other primates, including humans, because they grow and age faster. Therefore, the common marmoset model is effective in aging research. The current study investigated the aging process of the marmoset brain and provided an open MRI database of marmosets across a wide age range. The Brain/MINDS Marmoset Brain MRI Dataset contains brain MRI information from 216 marmosets ranging in age from 1 and 10 years. At the time of its release, it is the largest public dataset in the world. It also includes multi-contrast MRI images. In addition, 91 of 216 animals have corresponding high-resolution ex vivo MRI datasets. Our MRI database, available at the Brain/MINDS Data Portal, might help to understand the effects of various factors, such as age, sex, body size, and fixation, on the brain. It can also contribute to and accelerate brain science studies worldwide.

Diverse Configurations of Erroneous Predictive Coding Across Brain Hierarchies in a Non-Human Primate Model of Autism Spectrum Disorder

“…For each subject, the normalized spatial coefficients were then averaged across all significant ICs to obtain a joint topographic map (Figure 4A), from which we evaluated the relative contributions of three cortical areas: the posterior temporal cortex (pTC), the anterior temporal cortex (aTC), and the anterior prefrontal cortex (aPFC) (Figure 4B). The brain areas were identified based on the Marmoset 3D brain atlas Brain/MINDS NA216 [44] (see Methods). For each area, the relative contribution was quantified by the sum of the spatial distribution in the area divided by the total spatial distribution across all channels.…”

“…The coordinates of recording electrodes were identified on the basis of the combination of pre-acquired MR images and postoperative computer tomography images using AFNI software [78] (http://afni.nimh.nih.gov). Then, we estimated the location of each electrode on cortical areas by registering to the Marmoset 3D brain atlas Brain/MINDS NA216 [44] with AFNI and ANTS [79].…”

The Brain/MINDS Marmoset Connectivity Resource: An open-access platform for cellular-level tracing and tractography in the primate brain

“…We followed Bruker’s standard recommended settings for the diffusion directions during imaging [ 59 ]. Further details regarding the dMRI acquisition protocol can be found in [ 60 ].…”

The HABD: Home of All Biological Databases Empowering Biological Research With Cutting‐Edge Database Systems

“…The COVID-19 pandemic remains a rapidly evolving concern, primarily driven by the various SARS-CoV-2 strains. Computational scientists have responded by publishing numerous databases, each addressing specific aspects like image information in digital image databases (Batool et al, 2023;Hata et al, 2023) and genomic updates in genomic databases (Szklarczyk et al, 2023). To facilitate easy access to these invaluable resources with a single click, we have compiled a comprehensive dataset solely focusing on COVID-19 research databases.…”