Multi-modal brain magnetic resonance imaging database covering marmosets with a wide age range

Abstract

Magnetic resonance imaging (MRI) is a noninvasive neuroimaging method beneficial for the identification of normal developmental and aging processes and data sharing. Marmosets have a relatively shorter life expectancy (approximately 10 years) than other primates, including, humans because they grow and age faster. Hence, the common marmoset model is effective in aging research. The current study investigated the aging process of the marmoset brain and provided an open MRI database on marmosets with a wide age range. The Brain/MINDS Marmoset Brain MRI Dataset contains brain MRI information on 216 marmosets aged between 1 and 10 years. During its release date, it is the largest public dataset worldwide. Further, it comprises multi contrast MRI images. In addition, 91 of 216 animals have corresponding ex vivo high-resolution MRI datasets. Our MRI database, which is available at the Brain/MINDS Data portal might help understand the effects of different factors, such as age, sex, body size, and fixation, on the brain. Moreover, it can contribute to and accelerate brain science studies worldwide.

The Subcortical Atlas of the Marmoset (“SAM”) monkey based on high-resolution MRI and histology

“…We estimated and confirmed the atlas-based areal boundaries of subcortical areas by registering this standard ex vivo SAM template to multiple in vivo T2W marmoset MRI datasets of different age groups (control adults) (Liu et al . 2021; Hata et al . 2023).…”

“…We estimated and confirmed the atlas-based areal boundaries of subcortical areas by registering this standard ex vivo SAM template to multiple in vivo T2W marmoset MRI datasets of different age groups (control adults) (Liu et al 2021;Hata et al 2023). To this end, we developed a novel processing pipeline within AFNI and SUMA to optimally register the new SAM atlas to in vivo T1W multisubject population-based (Liu et al 2021) or in vivo T2W individual marmoset brain volumes (Figs.…”

“…For more details, see the results section and related Figure 7. The MR scanning methods to obtain T2W and T1W images of these control animals are described in the following publications (Liu et al 2021;Hata et al 2023).…”

“…Note the corresponding location of the deep brain regions in the control subjects (e.g., ac-anterior commissure; Bmc-basal nucleus of the amygdala, magnocellular division, indicated by cross-hair; cd-caudate; cla-claustrum; ica-anterior limb of the internal capsule; pu-putamen) closely matched with the SAM (A). The MRI volumes of these six control subjects were obtained from the publicly shared multimodal brain MRI database covering the marmosets with a wide age range (Hata et al 2023). Scale bars in A-H = 5 mm.…”

The HABD: Home of All Biological Databases Empowering Biological Research With Cutting‐Edge Database Systems

“…The COVID‐19 pandemic remains a rapidly evolving concern, primarily driven by the various SARS‐CoV‐2 strains. Computational scientists have responded by publishing numerous databases, each addressing specific aspects like image information in digital image databases (Batool et al., 2023; Hata et al., 2023) and genomic updates in genomic databases (Szklarczyk et al., 2023). To facilitate easy access to these invaluable resources with a single click, we have compiled a comprehensive dataset solely focusing on COVID‐19 research databases.…”