Multi-Mechanistic In Vitro Evaluation of Antihyperglycemic, Antioxidant and Antiglycation Activities of Three Phenolic-Rich Indian Red Rice Genotypes and In Silico Evaluation of Their Phenolic Metabolites

Haldipur, Ashrita C.; Srividya, N.

doi:10.3390/foods10112818

Cited by 3 publications

(1 citation statement)

References 81 publications

(99 reference statements)

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“…27 One of the most important phytochemicals used as antidiabetics are phenolic compounds, which act as antihyperglycemic and antioxidants. 28 This study evaluated sweet potato, cassava, and taro potencies as functional foods for managing diabetes mellitus based on data from the COVID-19 pandemic chemical composition and antioxidant activity. Tuber which has the highest phenolic compounds content was evaluated for in silico antidiabetic properties against several proteins, including ACE2, TMPRSS-2, and DPP IV.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Three Abundant Indonesian Traditional Tubers as Carbohydrate-Rich Food Alternatives for Diabetic Patients During the COVID-19 Pandemic

2022

TJNPR

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Diabetes is the tenth most common comorbidity in coronavirus disease, hence COVID-19 patients with this disease showed higher mortality rates and worse outcomes. Therefore, Management of diabetes during the pandemic became more critical, especially in ensuring patients consume functional foods containing diets, such as sweet potato, cassava, and taro, among the top ten abundant-traditional tubers in Indonesia. These foods are rich in protein, vitamin C, thiamine, riboflavin, niacin, and dietary fibre. Carbohydrate-rich foods, which constitute around 60% of the average diet should be considered. This study evaluated the potential of the three most consumed Indonesian tubers; sweet potato, cassava, and taro, as functional foods for managing diabetes during the pandemic. These foods were selected based on their chemical composition, antioxidant activity, and in silico molecular docking against COVID-19 and diabetes-related target proteins. The target proteins are ACE2 (angiotensinconverting enzyme 2), TMPRSS-2 (transmembrane serine protease 2), DPP IV (dipeptidyl peptidase IV), and α-glucosidase. The results showed that sweet potato has the highest phenolic compounds content and antioxidant activity, valued at 7.40 ± 0.20 mg/g GAE and 9.39 ± 0.3%, respectively. Moreover, molecular docking results indicated that sweet potato phenolic compounds, namely isorhamnetin, peonidin, and catechin against DPP IV, isorhamnetin, peonidin, and quercetin against ACE2, isorhamnetin and quercetin against α-glucosidase, and epicatechin against TMPRSS2 strongly interacted with the target proteins. In conclusion, cassava, taro, and sweet potato were the most potential functional foods for diabetes management during the pandemic.

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Section: Introductionmentioning

confidence: 99%

Evaluation of Three Abundant Indonesian Traditional Tubers as Carbohydrate-Rich Food Alternatives for Diabetic Patients During the COVID-19 Pandemic

2022

TJNPR

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Plant Foods and Their Phytochemicals as DPP IV and PTP1B Inhibitors for Blood Glucose Regulation: A Review

2023

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Valorization of Rice Husk (Oryza sativa L.) as a Source of In Vitro Antiglycative and Antioxidant Agents

Frosi

Vallelonga

Colombo

et al. 2023

Foods

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Rice husk is a good source of polyphenols, but it has not been efficiently utilized in food applications yet. Therefore, the aim of this work is to investigate, by in vitro assays, the polyphenolic extract (RHE) capacity of this waste to counteract the protein glycation at different stages of the reaction, correlating this activity with the antiradical properties. A microwave-assisted extraction using hydro-alcoholic solvents was applied to recover husk polyphenols. Extraction parameters were optimized by the design of the experiment. The extract with the highest polyphenolic recovery was obtained at 500 W and 90 °C, using 1:35 g of dry material/mL solvent, 80% ethanol, and a 5 min extraction time. Results highlight the ability of RHE to inhibit the formation of fructosamine in the early stage of glycation with a dose-dependent activity. Furthermore, in the middle stage of the reaction, the highest RHE tested concentration (2.5 mg/mL) almost completely inhibit the monitored advanced glycation end products (AGEs), as well as showing a good trapping ability against α-dicarbonyl intermediates. A strong positive correlation with antioxidant activity is also found. The obtained results are supported by the presence of ten polyphenols detected by RP-HPLC-DAD-ESI-MSn, mainly hydroxycinnamic acids and flavonoids, already reported in the literature as antiglycative and antioxidant agents.

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Multi-Mechanistic In Vitro Evaluation of Antihyperglycemic, Antioxidant and Antiglycation Activities of Three Phenolic-Rich Indian Red Rice Genotypes and In Silico Evaluation of Their Phenolic Metabolites

Cited by 3 publications

References 81 publications

Evaluation of Three Abundant Indonesian Traditional Tubers as Carbohydrate-Rich Food Alternatives for Diabetic Patients During the COVID-19 Pandemic

Evaluation of Three Abundant Indonesian Traditional Tubers as Carbohydrate-Rich Food Alternatives for Diabetic Patients During the COVID-19 Pandemic

Plant Foods and Their Phytochemicals as DPP IV and PTP1B Inhibitors for Blood Glucose Regulation: A Review

Valorization of Rice Husk (Oryza sativa L.) as a Source of In Vitro Antiglycative and Antioxidant Agents

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