Multi-matrix biomonitoring approach to assess exposure to metals and trace elements in the Lebanese population and associations with drinking water consumption

Eddine, Nessrine Nasser; Noisel, Nolwenn; Dieme, Denis; Asmar, Michèle Kosremelli; Issa, Sahar; Bouchard, Michèle

doi:10.1016/j.envres.2022.113982

Cited by 5 publications

(2 citation statements)

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“…In addition to foods, these trace elements can also be obtained from drinking water and environmental/occupational exposures [ 19 , 20 , 21 , 22 , 23 ]. However, it has been estimated that in the general population, diet is the primary factor strongly influencing daily intake of these essential elements [ 24 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

“…However, it has been estimated that in the general population, diet is the primary factor strongly influencing daily intake of these essential elements [ 24 , 25 ]. Meat and meat products have been reported as the main dietary source of Zn exposure in many countries [ 20 , 26 , 27 , 28 , 29 , 30 ]. Other items supplying greater Zn in Western diets include cereals, milk and dairy products, nuts, and seeds [ 31 , 32 ].…”

Section: Introductionmentioning

confidence: 99%

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Single and Combined Associations of Plasma and Urine Essential Trace Elements (Zn, Cu, Se, and Mn) with Cardiovascular Risk Factors in a Mediterranean Population

et al. 2022

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Trace elements are micronutrients that are required in very small quantities through diet but are crucial for the prevention of acute and chronic diseases. Despite the fact that initial studies demonstrated inverse associations between some of the most important essential trace elements (Zn, Cu, Se, and Mn) and cardiovascular disease, several recent studies have reported a direct association with cardiovascular risk factors due to the fact that these elements can act as both antioxidants and pro-oxidants, depending on several factors. This study aims to investigate the association between plasma and urine concentrations of trace elements and cardiovascular risk factors in a general population from the Mediterranean region, including 484 men and women aged 18–80 years and considering trace elements individually and as joint exposure. Zn, Cu, Se, and Mn were determined in plasma and urine using an inductively coupled plasma mass spectrometer (ICP-MS). Single and combined analysis of trace elements with plasma lipid, blood pressure, diabetes, and anthropometric variables was undertaken. Principal component analysis, quantile-based g-computation, and calculation of trace element risk scores (TERS) were used for the combined analyses. Models were adjusted for covariates. In single trace element models, we found statistically significant associations between plasma Se and increased total cholesterol and systolic blood pressure; plasma Cu and increased triglycerides and body mass index; and urine Zn and increased glucose. Moreover, in the joint exposure analysis using quantile g-computation and TERS, the combined plasma levels of Zn, Cu, Se (directly), and Mn (inversely) were strongly associated with hypercholesterolemia (OR: 2.03; 95%CI: 1.37–2.99; p < 0.001 per quartile increase in the g-computation approach). The analysis of urine mixtures revealed a significant relationship with both fasting glucose and diabetes (OR: 1.91; 95%CI: 1.01–3.04; p = 0.046). In conclusion, in this Mediterranean population, the combined effect of higher plasma trace element levels (primarily Se, Cu, and Zn) was directly associated with elevated plasma lipids, whereas the mixture effect in urine was primarily associated with plasma glucose. Both parameters are relevant cardiovascular risk factors, and increased trace element exposures should be considered with caution.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Single and Combined Associations of Plasma and Urine Essential Trace Elements (Zn, Cu, Se, and Mn) with Cardiovascular Risk Factors in a Mediterranean Population

et al. 2022

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Associations of Perinatal Metal and Metalloid Exposures with Early Child Behavioral Development Over Time in the New Hampshire Birth Cohort Study

et al. 2023

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BackgroundResearch on the neurodevelopmental effects of metal/metalloids has focused mainly on outcomes assessed at one time point, even though brain development progresses over time. We investigated biomarkers of perinatal exposure to metal/loids and changes in child behavior over time. MethodsWe followed 268 participants from the prospective New Hampshire Birth Cohort Study between birth and age ve years. We measured arsenic (As), copper (Cu), manganese (Mn), lead (Pb), selenium (Se) and zinc (Zn) in toenails from 6-week-old infants. The Behavioral Symptoms Index (BSI), externalizing, and internalizing symptoms were assessed using the Behavior Assessment System for Children, 2nd edition (BASC-2) at ages 3 and 5 years. Multivariable linear regression was used to estimate associations of metal/loids with behavior change, calculated as the difference in symptom raw scores between 3 and 5 years, in addition to the associations for symptom scores at 3 and 5 years separately. Sex-speci c associations were also explored using strati ed models and a sex-metal interaction term. ResultsAdjusted associations of metal/loids and change in behavior varied by exposure and outcome. Each 1 µg/g increase in toenail Cu was associated with improved behavior between 3 and 5 years [BSI: β= -3.88 (95%CI: -7.12, -0.64); Externalizing problems: β = -2.20 (95%CI: -4.07, -0.33)]. Increasing Zn was associated with increased externalizing behavior over time (β = 3.42 (95%CI: 0.60, 6.25). Sex-strati ed analyses suggested more pronounced associations among boys compared to girls. ConclusionsPerinatal exposure to metal/loids may alter behavioral development between ages 3 and 5 years.Findings support the need for more research on associations between metal/loids and neurodevelopment over longer time periods.

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Spatial distribution, impact factors, and potential health implications of trace elements in human hair from capital residents in China

et al. 2023

Chemosphere

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Multi-matrix biomonitoring approach to assess exposure to metals and trace elements in the Lebanese population and associations with drinking water consumption

Cited by 5 publications

References 79 publications

Single and Combined Associations of Plasma and Urine Essential Trace Elements (Zn, Cu, Se, and Mn) with Cardiovascular Risk Factors in a Mediterranean Population

Single and Combined Associations of Plasma and Urine Essential Trace Elements (Zn, Cu, Se, and Mn) with Cardiovascular Risk Factors in a Mediterranean Population

Associations of Perinatal Metal and Metalloid Exposures with Early Child Behavioral Development Over Time in the New Hampshire Birth Cohort Study

Spatial distribution, impact factors, and potential health implications of trace elements in human hair from capital residents in China

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