Multi-level magnetic microrobot delivery strategy within a hierarchical vascularized organ-on-a-chip

Abstract

We present a multi-level magnetic delivery strategy for robust and highly-efficient transportation of microrobots within the hierarchical vascularized organ-on-a-chip system.

Continuum Robots and Magnetic Soft Robots: From Models to Interdisciplinary Challenges for Medical Applications

“…Despite the preference for uniform magnetic fields due to their simplicity in modeling and predictability in operational contexts, such as in the case of filamentous magnetic soft robots [ 25 ], non-uniform magnetic fields have demonstrated undeniable advantages in specific specialized medical applications. Specifically, non-uniform magnetic fields offer enhanced capabilities for localized and adaptive manipulation, making them particularly suitable for interventions in complex and deep-seated tissue structures, such as aortic treatment ( Figure 1 -3a) [ 180 ], cancer therapy [ 181 , 182 , 183 ], neuro intervention ( Figure 1 -3b) [ 184 ], intravascular surgery ( Figure 1 -3c) [ 185 , 186 ], and endoscopic procedures ( Figure 1 -3d) [ 187 ], etc. [ 188 ].…”

Magnetic Microrobots for In Vivo Cargo Delivery: A Review

“…As shown in Figure 3c, MMR swarms, these magnetic spheres could be used as research subjects, simplifying individual robot design and focusing on flexible, programmable, and reconfigurable MMR swarms through magnetic field control [43,71,72]. However, these microrobots are limited to surface drug loading through chemical bonding or physical adsorption, restricting their capacity to transport cell-type cargoes.…”

“…In the study by Lu et al, a novel multi-level magnetic delivery approach was introduced, combining a tethered microrobotic guidewire with untethered swimming microrobots. This integration effectively addressed the limitations inherent to each type, facilitating the robust and efficient delivery of microrobots in complex in vivo environments over substantial distances [72].…”