Multi-layer PDMS films having antifouling property for biomedical applications

Mousavi, Maryam; Ghaleh, Hakimeh; Jalili, Kiyumars; Abbasi, Farhang

doi:10.1080/09205063.2020.1856300

Cited by 10 publications

(8 citation statements)

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“…Recent research validates that the toxicity of PDMS coatings is dependent on the concentration [ 36 ] and that the increase in the molecular weight of PDMS can improve the cell survival rate [ 37 ]. Additionally, special anti-fouling properties of PDMS products have been achieved for elastomers with polyurethane urea [ 38 ], as well as for PEGMA brushes obtained via the surface-initiated ATRP technique on roller-casted multiple PDMS layers [ 39 ]. Cosmetic products containing PDMS create a film on the surface of the skin, which protects against microbes and moisture loss without interfering with the skin’s physiological functions, while improving its appearance and condition [ 40 ].…”

Section: Introductionmentioning

confidence: 99%

Micellar Carriers of Active Substances Based on Amphiphilic PEG/PDMS Heterograft Copolymers: Synthesis and Biological Evaluation of Safe Use on Skin

Odrobińska

Skonieczna

Neugebauer

2021

IJMS

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Amphiphilic copolymers containing polydimethylsiloxane (PDMS) and polyethylene glycol methyl ether (MPEG) were obtained via an azide-alkyne cycloaddition reaction between alkyne-functionalized copolymer of MPEG methacrylate and azide-functionalized PDMS. “Click” reactions were carried out with an efficiency of 33–47% increasing grafting degrees. The grafted copolymers were able to carry out the micellization and encapsulation of active substances, such as vitamin C (VitC), ferulic acid (FA) and arginine (ARG) with drug loading content (DLC) in the range of 2–68% (VitC), and 51–89% (FA or ARG). In vitro release studies (phosphate buffer saline, PBS; pH = 7.4 or 5.5) demonstrated that the maximum release of active substances was mainly after 1–2 h. The permeability of released active substances through membrane mimicking skin evaluated by transdermal tests in Franz diffusion cells indicated slight diffusion into the solution (2–16%) and their remaining in the membrane. Studies on the selected carrier with FA showed no negative effect on cell viability, proliferation capacity or senescence, as well as cell apoptosis/necrosis differences or cell cycle interruption in comparison with control cells. These results indicated that the presented micellar systems are good candidates for carriers of cosmetic substances according to physicochemical characterization and biological studies.

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Section: Introductionmentioning

confidence: 99%

Micellar Carriers of Active Substances Based on Amphiphilic PEG/PDMS Heterograft Copolymers: Synthesis and Biological Evaluation of Safe Use on Skin

Odrobińska

Skonieczna

Neugebauer

2021

IJMS

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“…The number of BSA molecules adsorbed on the POEGMA brush grafted fibre mat surface (graft length of 30-units) was 82% lower than on the ungrafted sSEBS-PEDOT fibre mat surface, as shown in Figure 4 A. Such good fouling resistance is attributed to the hydrophilicity and the energy barrier created by the conformational entropy of the POEGMA brushes [ 19 , 46 ]. The surface hydration layer formed by the interaction between water and the POEGMA chains creates a steric hindrance against proteins approaching the surface [ 47 ].…”

Section: Resultsmentioning

confidence: 99%

“…The excellent antifouling properties of the surfaces grafted by the PEG polymer brushes were attributed to high surface coverage by the brushes, charge-neutrality of PEGs, protective water barrier properties, lack of hydrogen bond donating sites and the steric repulsion exhibited by long PEG chains [ 16 , 17 , 18 ]. For instance, Mousavi et al developed packaging for a biomedical implant based on medical-grade poly(dimethyl siloxane) (PDMS) [ 19 ]. To prevent protein and cell adhesion, POEGMA brushes were grafted onto PDMS, increasing the hydrophilicity and protein fouling resistance of the PDMS surface.…”

Section: Introductionmentioning

confidence: 99%

Conducting Polymer-Infused Electrospun Fibre Mat Modified by POEGMA Brushes as Antifouling Biointerface

et al. 2022

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Biofouling on surfaces, caused by the assimilation of proteins, peptides, lipids and microorganisms, leads to contamination, deterioration and failure of biomedical devices and causes implants rejection. To address these issues, various antifouling strategies have been extensively studied, including polyethylene glycol-based polymer brushes. Conducting polymers-based biointerfaces have emerged as advanced surfaces for interfacing biological tissues and organs with electronics. Antifouling of such biointerfaces is a challenge. In this study, we fabricated electrospun fibre mats from sulphonated polystyrene-block-poly(ethylene-ran-butylene)-block-polystyrene (sSEBS), infused with conducting polymer poly(3,4-ethylenedioxythiophene) (PEDOT) (sSEBS-PEDOT), to produce a conductive (2.06 ± 0.1 S/cm), highly porous, fibre mat that can be used as a biointerface in bioelectronic applications. To afford antifouling, here the poly(oligo (ethylene glycol) methyl ether methacrylate) (POEGMA) brushes were grafted onto the sSEBS-PEDOT conducting fibre mats via surface-initiated atom transfer radical polymerization technique (SI-ATRP). For that, a copolymer of EDOT and an EDOT derivative with SI-ATRP initiating sites, 3,4-ethylenedioxythiophene) methyl 2-bromopropanoate (EDOTBr), was firstly electropolymerized on the sSEBS-PEDOT fibre mat to provide sSEBS-PEDOT/P(EDOT-co-EDOTBr). The POEGMA brushes were grafted from the sSEBS-PEDOT/P(EDOT-co-EDOTBr) and the polymerization kinetics confirmed the successful growth of the brushes. Fibre mats with 10-mers and 30-mers POEGMA brushes were studied for antifouling using a BCA protein assay. The mats with 30-mers grafted brushes exhibited excellent antifouling efficiency, ~82% of proteins repelled, compared to the pristine sSEBS-PEDOT fibre mat. The grafted fibre mats exhibited cell viability >80%, comparable to the standard cell culture plate controls. Such conducting, porous biointerfaces with POEGMA grafted brushes are suitable for applications in various biomedical devices, including biosensors, liquid biopsy, wound healing substrates and drug delivery systems.

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“…Cross-linked polymers can be in the form of thermosets or elastomers. Polydimethylsiloxane (PDMS) is a widely used elastomer possessing various features such as its optical transparency, low manufacturing costs and thermal stability, which makes it suitable for a wide range of applications, including biomedical substrates, water treatment and microelectromechanical systems (MEMS) Johnston et al (2014); Chen et al (2015); Mousavi et al (2021); Maddah (2019); Schneider et al (2009).…”

Section: Introductionmentioning

confidence: 99%

Workflow for computational characterization of PDMS cross-linked systems

Kampmann

Dianat²,

Cuniberti³

2023

Front. Built Environ.

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The aim of this work is to demonstrate a computational workflow for the generation of cross-linkable viscoelastic polymers and the determination of elastic and hyperelastic properties by means of all-atoms classical molecular dynamics simulations, using polydimethylsiloxane (PDMS) as an example. To improve the computational efficiency of the workflow, a phenomenological description of the cross-linking process is chosen instead of a quantum mechanical description of the cross-linking mechanism. The structures produced differ in their conversion degree of cross-linking (cdc) of 60, 70, and 80 percent and their quantity ratio between polymer chains and cross-linking units of 2 to 1 and 5 to 1. In order to exclude finite size effects of the molecular systems as much as possible, large systems of about 40,000 atoms are considered. Furthermore, for each possible configuration from the combination of cdc and the ratio of polymer chains to cross-linking units, six structures different from each other are used. Tensile and compression tests are performed to determine mechanical properties. A dependence of stresses in the deformation direction on strain rate is found for strain rates 107, 108, and 109 1/s. As the cdc increases, an increase in the stress values is observed in the tensile tests. To determine the viscoelastic material properties, relaxation tests are performed following the tensile tests. Thereby, the determined relaxed stresses after the tensile test rise with the increase of the cdc. Furthermore, no large stress deviations, .34 MPa maximum, between structures differing by chain to linker ratio are observed with the Ogden model. The computational workflow shows that classical all-atom molecular dynamics simulations can be a suitable method for structure generation and subsequent characterization of elastic and hyperelastic properties of cross-linked polymers.

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Multi-layer PDMS films having antifouling property for biomedical applications

Cited by 10 publications

References 43 publications

Micellar Carriers of Active Substances Based on Amphiphilic PEG/PDMS Heterograft Copolymers: Synthesis and Biological Evaluation of Safe Use on Skin

Micellar Carriers of Active Substances Based on Amphiphilic PEG/PDMS Heterograft Copolymers: Synthesis and Biological Evaluation of Safe Use on Skin

Conducting Polymer-Infused Electrospun Fibre Mat Modified by POEGMA Brushes as Antifouling Biointerface

Workflow for computational characterization of PDMS cross-linked systems

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