Multi‐institutional validation of the 8th AJCC TNM staging system for gastric cancer: Analysis of survival data from high‐volume Eastern centers and the SEER database

Son, Taeil; Sun, Jiyu; Choi, Seohee; Cho, Gyu Seok; Kwon, In Gyu; Kim, Wook; Cheong, Jae‐Ho; Choi, Seung Ho; Noh, Sung Hoon; Woo, Yanghee; Fong, Yuman; Park, So Hee; Hyung, Woo Jin

doi:10.1002/jso.25639

Cited by 36 publications

(30 citation statements)

References 19 publications

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“…However, according to the TNM staging system, N0 and N+ cases are mixed, even in the same stage. While the revision of the 8th AJCC TNM staging system has made the prognosis of each stage even more uniform, even in the same stage, the survival curves may differ among subgroups (25). We, therefore, attempted to confirm the independence of LVI prognosis and stratify the prognostic impact of LVI in large cohort studies by T and N factors rather than by TNM stage.…”

Section: Discussionmentioning

confidence: 99%

The Clinical Significance of Lymphovascular Invasion in Gastric Cancer

Fujikawa

Koumori

Watanabe

et al. 2020

In Vivo

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Background/Aim: Lymphovascular invasion (LVI) is recognized as a prognostic predictor of recurrence in certain carcinomas. According to current Japanese guidelines, however, in gastric cancer, LVI is not clinically useful information, except for predicting the curability of endoscopic resection. We clarified the clinical significance of LVI in gastric cancer and its correlation with disease prognosis. Patients and Methods: A total of 2,090 cases of gastric cancer undergoing radical gastrectomy were enrolled. The correlation of LVI and other histopathological factors was evaluated with regards to patient prognosis. Results: LVI(+) was noted in 894 cases. A multivariate analysis showed that pT, pN, and LVI were independent risk factors for patient prognosis. In pT2-4 patients with nodal metastasis, a significant difference was revealed, and the 5year overall survival rates in LVI(+) cases were lower than those in LVI(-) (60.9% vs. 76.7%, p=0.005). Conclusion: LVI in gastric cancer is an independent prognostic factor, and tends to worsen prognosis, especially in advanced cancers with lymph node metastases.

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Section: Discussionmentioning

confidence: 99%

The Clinical Significance of Lymphovascular Invasion in Gastric Cancer

Fujikawa

Koumori

Watanabe

et al. 2020

In Vivo

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“…As stated by the American Joint Committee on Cancer (AJCC), the tumor lymph node metastasis (TNM) staging system has been widely used to predict the prognosis of cancer patients ( 7 , 8 ). The 8th AJCC staging system for GC has been assessed by several large centers, providing excellent results in assessing the prognosis ( 9 , 10 ).…”

Section: Introductionmentioning

confidence: 99%

Development and Validation of a Prognostic Nomogram for Gastric Signet Ring Cell Carcinoma: A Multicenter Population-Based Study

et al. 2021

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BackgroundGastric signet ring cell carcinoma (GSRCC) is a rare disease associated with poor prognosis. A prognostic nomogram was developed and validated in this study to assess GSRCC patients’ overall survival (OS).MethodsPatients diagnosed with GSRCC from the Surveillance, Epidemiology, and End Results (SEER) database (2004–2016) and the First Hospital of China Medical University (CMU1h) were enrolled in this retrospective cohort study. Univariate and multivariate COX analysis was used to determine independent prognostic factors to construct the prognostic nomogram. Predictions were evaluated by the C-index and calibration curve. In addition, the receiver operating characteristic (ROC) curve, decision curve analysis (DCA), and Kaplan-Meier analysis were employed to assess the clinical utility of the survival prediction model.ResultsPatients were classified into two cohorts. We randomly divided patients in the SEER database and CMU1h cohort into a training group (n=3068, 80%) and a validation group (n=764, 20%). Age, race, T stage, N stage, M stage, therapy, and tumor size were significantly associated with the prognosis of GSRCC patients. On this basis, a nomogram was constructed, with a C-index in the training and the validation cohorts at 0.772 (95% CI: 0.762–0.782) and 0.774 (95% CI: 0.752–0.796), respectively. The accuracy of the generated nomogram was verified through calibration plots. Similarly, compared with the traditional AJCC staging system, the results of the area under curve (AUC) calculated by ROC, DCA, and Kaplan-Meier curves, demonstrated a good predictive value of the constructed nomogram, compared to the traditional AJCC staging system.ConclusionIn the present study, seven independent prognostic factors of GSRCC were screened out. The established nomogram models based on seven variables provided a visualization of each prognostic factor’s risk and assisted clinicians in predicting the 1-, 3-, and 5-year OS of GSRCC.

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“…Gastric cancer (GC) is a common malignant tumor and ranks the second leading cause of cancer-related death in the world, making it a serious threat to human health and quality of life. According to GLOBACAN statistics, approximately 1,033,000 new cases are diagnosed and 783,000 deaths are estimated worldwide in 2018, the majority of which are diagnosed middle and advanced tumors (at stage II or III) ( Bray et al, 2018 ; Son et al, 2019 ). Thus, accurate and early diagnosis of GC remains a significant clinical challenge.…”

Section: Introductionmentioning

confidence: 99%

Targeting Fluorescence Imaging of RGD-Modified Indocyanine Green Micelles on Gastric Cancer

Shao

Zheng

Feng

et al. 2020

Front. Bioeng. Biotechnol.

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Early diagnosis and complete resection of the tumor is an important way to improve the quality of life of patients with gastric cancer. In recent years, near-infrared (NIR) materials show great potential in fluorescence-based imaging of the tumors. To realize a satisfying intraoperative fluorescence tumor imaging, there are two pre-requirements. One is to obtain a stable agent with a relatively longer circulation time. The second is to make it good biocompatible and specific targeting to the tumor. Here, we developed an RGD-modified Distearyl acylphosphatidyl ethanolamine-polyethylene glycol micelle (DSPE-PEG-RGD) to encapsulate indocyanine green (ICG) for targeting fluorescence imaging of gastric cancer, aimed at realizing tumor-targeted accumulation and NIR imaging. 1 H NMR spectroscopy confirmed its molecular structure. The characteristics and stability results indicated that the DSPE-PEG-RGD@ICG had a relatively uniform size of <200 nm and longer-term fluorescence stability. RGD peptides had a high affinity to integrin α v β 3 and the specific targeting effect on SGC7901 was assessed by confocal microscopy in vitro. Additionally, the results of cytotoxicity and blood compatibility in vitro were consistent with the acute toxicity test in vivo, which revealed good biocompatibility. The biodistribution and tumor targeting image of DSPE-PEG-RGD@ICG were observed by an imaging system in tumor-bearing mice. DSPE-PEG-RGD@ICG demonstrated an improved accumulation in tumors and longer circulation time when compared with free ICG or DSPE-PEG@ICG. In all, DSPE-PEG-RGD@ICG demonstrated ideal properties for tumor target imaging, thus, providing a promising way for the detection and accurate resection of gastric cancer.

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Multi‐institutional validation of the 8th AJCC TNM staging system for gastric cancer: Analysis of survival data from high‐volume Eastern centers and the SEER database

Cited by 36 publications

References 19 publications

The Clinical Significance of Lymphovascular Invasion in Gastric Cancer

The Clinical Significance of Lymphovascular Invasion in Gastric Cancer

Development and Validation of a Prognostic Nomogram for Gastric Signet Ring Cell Carcinoma: A Multicenter Population-Based Study

Targeting Fluorescence Imaging of RGD-Modified Indocyanine Green Micelles on Gastric Cancer

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