Multi‐Hierarchical Fe Single Atom Nanozymes with Axially‐Coordinated O‐Fe‐N4 Active Centers Reshape Macrophage Epigenetics Against Immunosuppression
Qin Wang,
Xiaoqi Zhu,
Binxu Yin
et al.
Abstract:Immunosuppression is ubiquitous in solid tumors, characterized by few cytotoxic T infiltrations, abundant inflammation enrichment, immunosuppressive cell recruitment, etc., which is especially potentiated by incomplete tumor resection. In this report, multi‐hierarchical Fe single‐atom nanozymes (SAzymes) featuring axially‐coordinated O‐Fe‐N4 active centers are constructed to reshape tumor‐associated macrophages (TAMs) epigenetics via repolarizing their phenotypes, which is highly profitable for mitigating tumo… Show more
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