Multi-functional chitosan polymeric micelles as oral paclitaxel delivery systems for enhanced bioavailability and anti-tumor efficacy

Chen, Tiane; Tu, Liangxing; Wang, Ge; Qi, Na; Wu, Wei; Zhang, Wei; Jiao, Feng

doi:10.1016/j.ijpharm.2020.119105

Cited by 72 publications

(27 citation statements)

References 51 publications

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“…CMC value is a point at which self-assembly occurs and the addition of surfactant after this point is no longer reduces the surface tension. Several techniques have been used in revealing the CMC value such as fluorescence probe [84], surface plasmon resonance [85], dye solubilization [86], tensiometer [87], viscometry [88], calorimetry [89] and electrical conductivity [90].…”

Section: Characterizations For Preformulationmentioning

confidence: 99%

Synthesis and Technology of Nanoemulsion-Based Pesticide Formulation

2020

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Declines in crop yield due to pests and diseases require the development of safe, green and eco-friendly pesticide formulations. A major problem faced by the agricultural industry is the use of conventional agrochemicals that contribute broad-spectrum effects towards the environment and organisms. As a result of this issue, researchers are currently developing various pesticide formulations using different nanotechnology approaches. The progress and opportunities in developing nanoemulsions as carriers for plant protection or nanodelivery systems for agrochemicals in agricultural practice have been the subject of intense research. New unique chemical and biologic properties have resulted in a promising pesticide nanoformulations for crop protection. These innovations—particularly the nanoemulsion-based agrochemicals—are capable of enhancing the solubility of active ingredients, improving agrochemical bioavailability, and improving stability and wettability properties during the application, thus resulting in better efficacy for pest control and treatment. All of these—together with various preparation methods towards a greener and environmentally friendly agrochemicals—are also discussed and summarized in this review.

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Section: Characterizations For Preformulationmentioning

confidence: 99%

Synthesis and Technology of Nanoemulsion-Based Pesticide Formulation

2020

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“…Altogether, the results showed that PTX-micelles altered pharmacokinetics and increased the therapeutic effect of paclitaxel. The bioavailability of micelles was increased 3.80-fold with respect to PTX and, as a consequence, the anti-tumor efficacy was also enhanced [ 98 ].…”

Section: Introductionmentioning

confidence: 99%

A Compressive Review about Taxol®: History and Future Challenges

et al. 2020

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Taxol®, which is also known as paclitaxel, is a chemotherapeutic agent widely used to treat different cancers. Since the discovery of its antitumoral activity, Taxol® has been used to treat over one million patients, making it one of the most widely employed antitumoral drugs. Taxol® was the first microtubule targeting agent described in the literature, with its main mechanism of action consisting of the disruption of microtubule dynamics, thus inducing mitotic arrest and cell death. However, secondary mechanisms for achieving apoptosis have also been demonstrated. Despite its wide use, Taxol® has certain disadvantages. The main challenges facing Taxol® are the need to find an environmentally sustainable production method based on the use of microorganisms, increase its bioavailability without exerting adverse effects on the health of patients and minimize the resistance presented by a high percentage of cells treated with paclitaxel. This review details, in a succinct manner, the main aspects of this important drug, from its discovery to the present day. We highlight the main challenges that must be faced in the coming years, in order to increase the effectiveness of Taxol® as an anticancer agent.

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“…Second, some formulations can improve mucoadhesion due to the interaction between the nanocarrier (positive charge) and mucin (negative charge). For example, chitosan and carboxymethyl chitosan have strong mucoadhesive properties and can be used to prepare micelles with enhanced mucoadhesion [ 44 , 137 ].…”

Section: Recently Developed Formulations To Bypass P-gp and Enhance Oral Bioavailability Of P-gp Substratesmentioning

confidence: 99%

Pharmaceutical Formulations with P-Glycoprotein Inhibitory Effect as Promising Approaches for Enhancing Oral Drug Absorption and Bioavailability

2021

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P-glycoprotein (P-gp) is crucial in the active transport of various substrates with diverse structures out of cells, resulting in poor intestinal permeation and limited bioavailability following oral administration. P-gp inhibitors, including small molecule drugs, natural constituents, and pharmaceutically inert excipients, have been exploited to overcome P-gp efflux and enhance the oral absorption and bioavailability of many P-gp substrates. The co-administration of small molecule P-gp inhibitors with P-gp substrates can result in drug–drug interactions and increased side effects due to the pharmacological activity of these molecules. On the other hand, pharmaceutically inert excipients, including polymers, surfactants, and lipid-based excipients, are safe, pharmaceutically acceptable, and are not absorbed from the gut. Notably, they can be incorporated in pharmaceutical formulations to enhance drug solubility, absorption, and bioavailability due to the formulation itself and the P-gp inhibitory effects of the excipients. Different formulations with inherent P-gp inhibitory activity have been developed. These include micelles, emulsions, liposomes, solid lipid nanoparticles, polymeric nanoparticles, microspheres, dendrimers, and solid dispersions. They can bypass P-gp by different mechanisms related to their properties. In this review, we briefly introduce P-gp and P-gp inhibitors, and we extensively summarize the current development of oral drug delivery systems that can bypass and inhibit P-gp to improve the oral absorption and bioavailability of P-gp substrates. Since many drugs are limited by P-gp-mediated efflux, this review is helpful for designing suitable formulations of P-gp substrates to enhance their oral absorption and bioavailability.

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Multi-functional chitosan polymeric micelles as oral paclitaxel delivery systems for enhanced bioavailability and anti-tumor efficacy

Cited by 72 publications

References 51 publications

Synthesis and Technology of Nanoemulsion-Based Pesticide Formulation

Synthesis and Technology of Nanoemulsion-Based Pesticide Formulation

A Compressive Review about Taxol®: History and Future Challenges

Pharmaceutical Formulations with P-Glycoprotein Inhibitory Effect as Promising Approaches for Enhancing Oral Drug Absorption and Bioavailability

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