Multi-epitope vaccine design of African swine fever virus considering T cell and B cell immunogenicity
Ting-Yu Chen,
Yann-Jen Ho,
Fang-Yu Ko
et al.
Abstract:T and B cell activation are equally important in triggering and orchestrating adaptive host responses to design multi-epitope African swine fever virus (ASFV) vaccines. However, few design methods have considered the trade-off between T and B cell immunogenicity when identifying promising ASFV epitopes. This work proposed a novel Pareto front-based ASFV screening method PFAS to identify promising epitopes for designing multi-epitope vaccines utilizing five ASFV Georgia 2007/1 sequences. To accurately predict T… Show more
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