Multi-epitope vaccine against SARS-CoV-2 targeting the spike RBD: an immunoinformatics approach
Yasamin Pahlavan,
Omid Yeganeh,
Vahid Asghariazar
et al.
Abstract:Aim: We designed a SARS-CoV-2 epitope vaccine based on the receptor-binding domain (RBD) in virus spike protein. Methods: RT-PCR performed on nasopharyngeal swab COVID-19 patients. After registering RBD region in the GenBank, physicochemical parameters, secondary structure, homology modeling, 3D structure of RBD region and antigenicity were determined using ProtParam ExPASy, PSIPRED, MolProbity, IEDB and Vaxijen online tools, respectively. Results: B and T cell epitopes were predicted in terms of non-allergeni… Show more
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