Multi-drug Resistant Tuberculosis; Early Experiences Of Two Irish Tertiary Referral Centres

Kennedy, Barry; O'Connor, Bernie; Korn, Bettina; Lyons, Owen D.; Gargoum, Fatma; Gibbons, Noel; O’Connor, Terence M.; Keane, Joseph

doi:10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a3152

Cited by 5 publications

(4 citation statements)

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“…Injectable drugs-including capreomycin and the aminoglycosides kanamycin and amikacincan cause permanent hearing loss in as many as 60% of people who receive them as part of treatment for multidrug-resistant tuberculosis. 3 Ironically, no injectable drug has been assessed in a randomised controlled trial for multidrug-resistant tuberculosis, and observational studies of their effectiveness show mixed results. 4 Despite this, injectable drugs are still recommended as key drugs for the management of multidrug-resistant tuberculosis.…”

Section: Reducing Harm In the Treatment Of Multidrug-resistant Tubercmentioning

confidence: 99%

Reducing harm in the treatment of multidrug-resistant tuberculosis

Reuter

Furin

2018

The Lancet

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Section: Reducing Harm In the Treatment Of Multidrug-resistant Tubercmentioning

confidence: 99%

Reducing harm in the treatment of multidrug-resistant tuberculosis

Reuter

Furin

2018

The Lancet

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“…Several antibiotics have been developed to control bacterial infections after penicillin discovery [ 1 ]. However, the resistance of bacteria to several antibiotics has developed and become a major global problem [ 2 ]. The resistance development rate is affected by several factors, including excessive use and abuse of antibiotics [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Biological Insights of Fluoroaryl-2,2′-Bichalcophene Compounds on Multi-Drug Resistant Staphylococcus aureus

et al. 2020

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Resistance of bacteria to multiple antibiotics is a significant health problem; hence, to continually respond to this challenge, different antibacterial agents must be constantly discovered. In this work, fluoroaryl-2,2′-bichalcophene derivatives were chemically synthesized and their biological activities were evaluated against Staphylococcus aureus (S. aureus). The impact of the investigated bichalcophene derivatives was studied on the ultrastructural level via scanning electron microscopy (SEM), molecular level via sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) method and on the biofilm inhibition via the electrochemical biosensors. Arylbichalcophenes’ antibacterial activity against S. aureus was affected by the presence and location of fluorine atoms. The fluorobithiophene derivative MA-1156 displayed the best minimum inhibitory concentration (MIC) value of 16 µM among the tested fluoroarylbichalcophenes. Over a period of seven days, S. aureus did not develop any resistance against the tested fluoroarylbichalcophenes at higher concentrations. The impact of fluoroarylbichalcophenes was strong on S. aureus protein pattern showing high degrees of polymorphism. SEM micrographs of S. aureus cells treated with fluoroarylbichalcophenes displayed smaller cell-sizes, fewer numbers, arranged in a linear form and some of them were damaged when compared to the untreated cells. The bioelectrochemical measurements demonstrated the strong sensitivity of S. aureus cells to the tested fluoroarylbichalcophenes and an antibiofilm agent. Eventually, these fluoroarylbichalcophene compounds especially the MA-1156 could be recommended as effective antibacterial agents.

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“…Over the past few years, the development of bacterial resistance to antibiotics has been reported and resistance to multiple antimicrobial agents has become a major health problem. 1 A continuous discovery of new anti-infectious agents is urgently needed owing to the progress of antibiotic resistance in almost all clinically significant pathogens. 2 Cancer is a disease that still intrigues the scientific community stimulating their interest in finding novel chemotherapeutic agents effective for the management and remediation of this life-threatening ailment.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, antimicrobial, and antiproliferative activities of substituted phenylfuranylnicotinamidines

Youssef¹,

Arafa²,

Ismail³

2016

DDDT

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This research work deals with the design and synthesis of a series of substituted phenylfuranylnicotinamidines 4a–i. Facile preparation of the target compounds was achieved by Suzuki coupling-based synthesis of the nitrile precursors 3a–i, followed by their conversion to the corresponding nicotinamidines 4a–i utilizing LiN(TMS)2. The antimicrobial activities of the newly synthesized nicotinamidine derivatives were evaluated against the Gram-negative bacterial strains Escherichia coli and Pseudomonas aeruginosa as well as the Gram-positive bacterial strains Staphylococcus aureus and Bacillus megaterium. The minimum inhibitory concentration values of nicotinamidines against all tested microorganisms were in the range of 10–20 μM. In specific, compounds 4a and 4b showed excellent minimum inhibitory concentration values of 10 μM against Staphylococcus aureus bacterial strain and were similar to ampicillin as an antibacterial reference. On the other hand, selected nicotinamidine derivatives were biologically screened for their cytotoxic activities against a panel of 60 cell lines representing nine types of human cancer at a single high dose at National Cancer Institute, Bethesda, MD, USA. Nicotinamidines showing promising activities were further assessed in a five-dose screening assay to determine their compound concentration causing 50% growth inhibition of tested cell (GI50), compound concentration causing 100% growth inhibition of tested cell (TGI), and compound concentration causing 50% lethality of tested cell (LC50) values. Structure-activity relationship studies demonstrated that the activity of members of this series can be modulated from cytostatic to cytotoxic based on the substitution pattern/nature on the terminal phenyl ring. The most active compound was found to be 4e displaying a submicromolar GI50 value of 0.83 μM, with TGI and LC50 values of 2.51 and 100 μM, respectively. Finally, the possible underlying mechanism of action of this series of compounds was investigated by determining their nuclease-like DNA degradation ability in addition to their antioxidant power and all monocations proved to be effective in all assays.

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Multi-drug Resistant Tuberculosis; Early Experiences Of Two Irish Tertiary Referral Centres

Cited by 5 publications

References 0 publications

Reducing harm in the treatment of multidrug-resistant tuberculosis

Reducing harm in the treatment of multidrug-resistant tuberculosis

Biological Insights of Fluoroaryl-2,2′-Bichalcophene Compounds on Multi-Drug Resistant Staphylococcus aureus

Synthesis, antimicrobial, and antiproliferative activities of substituted phenylfuranylnicotinamidines

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