Multi-Drug Resistant Pathogenic Escherichia coli Isolated from Wild Birds, Chicken, and the Environment in Malaysia

Mohamed, Mohamed-Yousif Ibrahim; Abu, Jalila; Zakaria, Zunita; Rashid, Abdul; Aziz, Saleha Abdul; Bitrus, Asinamai Athliamai; Habib, Ihab

doi:10.3390/antibiotics11101275

Cited by 9 publications

(15 citation statements)

References 35 publications

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“…Animal waste, sewage from farming operations, manure/slurries used as fertilizers or for silage preparation, and livestock grazing contribute to the infection and reinfection of livestock. The presence of E. coli in the soil promotes its spread among livestock, and its presence in the environment poses a risk of human infections (Mohamed et al, 2022).…”

Section: Discussionmentioning

confidence: 99%

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Livestock and environment as potential sources and reservoirs for multi-drug resistant Escherichia coli in Malaysia: A Systematic Review

Lawal,

Aklilu,

Kamaruzzaman

et al. 2024

VIS

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Pathogenic Escherichia coli (E. coli) is a significant foodborne pathogen that poses a serious global public health risk. These pathogenic strains of E. coli can be found in various environments such as soil, water, livestock, livestock products, and humans. This review aims to evaluate the role of livestock and the environment as potential sources and reservoirs of pathogenic E. coli in Malaysia over the past two decades. A systematic search was conducted on PubMed, Scopus, Web of Science, and Google Scholar databases using standardized keywords (Escherichia coli, Livestock, Abattoir workers, Farm workers, and Malaysia) to identify relevant original research articles published between 2001 and 2023 and our systematic review protocol was published in Prospero (Registration number: CRD42023433199). A total of 20 eligible articles were included in this review. The prevalence of multi-drug resistant E. coli among livestock production system and the environment, ranged from 4% to 100%. E. coli strains isolated from livestock production systems and environment in Malaysia exhibited high potential for pathogenicity, with diverse enterotoxins, genes associated with antimicrobial resistance, and virulence factors. Phylogroup B and D were noted among the E. coli isolates indicating that the strains in Malaysia are highly virulent and extra-intestinal. High levels of resistance to antimicrobials particularly ESBL and colistin which are last resort antimicrobials were noted. Butchering or processing of livestock, contamination of plants via contaminated waterways or livestock manure are the main sources and reservoir for E. coli to spread in Malaysia. Continued surveillance, monitoring and a comprehensive 'One Health' approach are recommended to effectively prevent and control livestock drug-resistant E.coli strains throughout the country.

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Section: Discussionmentioning

confidence: 99%

“…These serotypes are responsible for foodborne infections in both livestock and humans and are referred to as zoonotic E. coli. The detection of Shiga-like toxins is a valuable tool for identifying entero-hemorrhagic E. coli strains (Vieira, 2010;Mohamed et al, 2022).…”

Section: Discussionmentioning

confidence: 99%

Livestock and environment as potential sources and reservoirs for multi-drug resistant Escherichia coli in Malaysia: A Systematic Review

Lawal,

Aklilu,

Kamaruzzaman

et al. 2024

VIS

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“…Hasan et al [ 223 ] discovered that E. coli isolated from both domestic and wild birds was most commonly resistant to tetracycline, ampicillin, trimethoprim/sulfamethoxazole, and nalidixic acid, while Nowaczek et al [ 224 ] found E. coli isolated from free-living birds to be resistant to gentamicin too. On average, MDR was found in 42.7% of the isolates obtained from avian samples [ 223 , 224 , 225 , 226 ]. In the treatment of infections caused by E. coli , such as those acquired in the community or a hospital setting, the typical approach has been to use first-line antibiotics.…”

Section: Antimicrobial Resistance Profiles Of Bacteria Isolated From ...mentioning

confidence: 99%

Pathogenic Bacteria in Free-Living Birds, and Its Public Health Significance

Kobuszewska,

Wysok

2024

Animals

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Birds that roam freely, particularly those that migrate, have the potential to carry a range of diseases that can be passed on to humans. The vast movement of these birds across diverse environments and urban areas can contribute to the spread of bacteria over long distances, impacting both human and animal populations. Stress, overcrowding, and human interaction can also play a role in the transmission of infectious diseases among birds and humans. Therefore, it is crucial to comprehend the intricate connections between birds, vectors, zoonotic pathogens, and the environment, especially given the increasing urbanization and emergence of zoonotic illnesses. This review aims to provide a systematic overview of the significance of avian species in transmitting bacterial pathogens that pose a risk to public health.

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“…An increase in STEC antibiotic resistance is another major issue that we are facing currently. STEC resistant to various broad-spectrum antibiotics has been isolated from livestock, wildlife sources, and the environment [30,67,177,178]. The use of antibiotic growth promoters (AGPs) has further enhanced this problem of antibiotic resistance in STEC.…”

Section: Rise In Antibiotic-resistant Strainsmentioning

confidence: 99%

Prevalence and Implications of Shiga Toxin-Producing E. coli in Farm and Wild Ruminants

Ray

Singh

2022

Pathogens

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Shiga-toxin-producing Escherichia coli (STEC) is a food-borne pathogen that causes human gastrointestinal infections across the globe, leading to kidney failure or even death in severe cases. E. coli are commensal members of humans and animals’ (cattle, bison, and pigs) guts, however, may acquire Shiga-toxin-encoded phages. This acquisition or colonization by STEC may lead to dysbiosis in the intestinal microbial community of the host. Wildlife and livestock animals can be asymptomatically colonized by STEC, leading to pathogen shedding and transmission. Furthermore, there has been a steady uptick in new STEC variants representing various serotypes. These, along with hybrids of other pathogenic E. coli (UPEC and ExPEC), are of serious concern, especially when they possess enhanced antimicrobial resistance, biofilm formation, etc. Recent studies have reported these in the livestock and food industry with minimal focus on wildlife. Disturbed natural habitats and changing climates are increasingly creating wildlife reservoirs of these pathogens, leading to a rise in zoonotic infections. Therefore, this review comprehensively surveyed studies on STEC prevalence in livestock and wildlife hosts. We further present important microbial and environmental factors contributing to STEC spread as well as infections. Finally, we delve into potential strategies for limiting STEC shedding and transmission.

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Multi-Drug Resistant Pathogenic Escherichia coli Isolated from Wild Birds, Chicken, and the Environment in Malaysia

Cited by 9 publications

References 35 publications

Livestock and environment as potential sources and reservoirs for multi-drug resistant Escherichia coli in Malaysia: A Systematic Review

Livestock and environment as potential sources and reservoirs for multi-drug resistant Escherichia coli in Malaysia: A Systematic Review

Pathogenic Bacteria in Free-Living Birds, and Its Public Health Significance

Prevalence and Implications of Shiga Toxin-Producing E. coli in Farm and Wild Ruminants

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