Multi-drug-resistant<i>Enterococcus</i>spp. as a cause of non-responsive septic synovitis in three horses

Herdan, C; Acke, Els; Dicken, Matthew S.; Archer, R. M.; Forsyth, S F; Gee, Erica K.; Pauwels, F E T

doi:10.1080/00480169.2011.651702

Cited by 31 publications

(27 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…causing musculoskeletal infections have been reported (Herdan et al, 2012;Theelen et al, 2014). Ampicillin alone or in combination with sulbactam and chloramphenicol remain reasonable treatment options (Weese, 2009;Theelen et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

A retrospective analysis of antimicrobial resistance in bacterial pathogens in an equine hospital (2012–2015)

Spijk¹,

Schmitt²,

Fürst³

et al. 2016

SAT

View full text Add to dashboard Cite

Antimicrobial resistance has become an important concern in veterinary medicine. The aim of this study was to describe the rate of antimicrobial resistance in common equine pathogens and to determine the occurrence of multidrug-resistant isolates. A retrospective analysis of all susceptibility testing results from bacterial pathogens cultured from horses at the University of Zurich Equine Hospital (2012-2015) was performed. Strains exhibiting resistance to 3 or more antimicrobial categories were defined as multidrug-resistant. Susceptibility results from 303 bacterial pathogens were analyzed, most commonly Escherichia coli (60/303, 20%) and Staphylococcus aureus (40/303, 13%). High rates of acquired resistance against commonly used antimicrobials were found in most of the frequently isolated equine pathogens. The highest rate of multidrug resistance was found in isolates of Acinetobacter baumannii (23/24, 96%), followed by Enterobacter cloacae complex (24/28, 86%) and Escherichia coli (48/60, 80%). Overall, 60% of Escherichia coli isolates were phenotypically ESBL-producing and 68% of Staphylococcus spp. were phenotypically methicillin-resistant. High rates of acquired antimicrobial resistance towards commonly used antibiotics are concerning and underline the importance of individual bacteriological and anti microbial susceptibility testing to guide antimicrobial therapy. Minimizing and optimizing antimicrobial therapy in horses is needed. Keywords: horse, multidrug-resistant (MDR) bacteria, methicillin-resistant staphylococci (MRS), ESBL-producing

show abstract

Section: Discussionmentioning

confidence: 99%

A retrospective analysis of antimicrobial resistance in bacterial pathogens in an equine hospital (2012–2015)

Spijk¹,

Schmitt²,

Fürst³

et al. 2016

SAT

View full text Add to dashboard Cite

show abstract

“…Streptococcus infantis is described as a commensal of the upper respiratory tract in human medicine (Bek-Thomsen et al 2008). The pathogenicity of Enterococcus durans was not clearly demonstrated in horses (Wintzer 1999), while the E. faecalis is associated with endocarditis (Bolin et al 2005), with the microflora of chronic wounds (Freeman et al 2009), and with synovitis (Herdan et al 2012).…”

mentioning

confidence: 99%

Gram-positive aerobic and microaerophilic microorganisms isolated from pathological processes and lesions of horses

Bzdil¹,

Holý²,

Toporčák³

2017

Vet. Med. - Czech

View full text Add to dashboard Cite

ABSTRACT:The aim of this study was to characterise the genera and species of Gram-positive aerobic and microaerophilic microorganisms isolated from pathological processes and lesions in horses. In the period 2009-2014, 449 clinical samples from horses were examined. Of these, 229 (51%) were collected from the respiratory tract, 121 (26.9%) from the skin, 40 (8.9%) from the gastrointestinal tract, 40 (8.9%) from the eyes, 8 (1.8%) from the urinary tract, 6 (1.3%) from the musculoskeletal system, 4 (0.9%) from the lymphatic system and 1 (0.2%) from milk. The isolates were presumptively identified phenotypically, and identification was confirmed by molecular phenotypic MALDI-TOF. The most frequently detected strains (n = 330) were Staphylococcus spp., Streptococcus spp., Corynebacterium spp. with prevalence rates of 37.2%, 23.4% and 7.6%, respectively. In addition, 24 other taxa were identified, including Enterococcus spp., Bacillus spp., Trueperella pyogenes, Aerococcus viridans, Dermatophilus congolensis, Lysinibacillus fusiformis, Nocardiopsis alba and Streptomyces spp. Most of these are described as opportunistic pathogens of animals, including horses. Antibiotic susceptibility was tested using the disc diffusion method. Florfenicol and amoxycillin with clavulanic acid were the most effective antibiotics. The susceptibility to florfenicol was 100% for tested strains of Bacillus spp., Lysinibacillus spp., Corynebacterium spp., Dermatophilus congolensis, Streptococcus spp., Enterococcus spp., Aerococcus spp., Nocardiopsis alba and Trueperella pyogenes. The susceptibilities of Staphylococcus aureus and other staphylococci to florfenicol were 96.2% and 98.5% in tested strains, respectively. Amoxycillin with clavulanic acid exhibited 100% effectiveness against Corynebacterium spp., Dermatophilus congolensis, Streptococcus spp., Aerococcus spp., Enterococcus spp., Streptomyces spp., Nocardiopsis alba and Trueperella pyogenes tested strains. The susceptibilities of Staphylococcus aureus, other staphylococci and Bacillus/Lysinibacillus spp. to amoxycillin with clavulanic acid were 89.8%, 98.8% and 20.0% of tested strains, respectively.

show abstract

“…While we learn about antimicrobial resistance in human and small animal patients with methicillin‐resistant Staphylococcus aureus (MRSA), vancomycin‐resistant enterococci (VRE), methicillin‐resistant S. pseudointermedius (MRSP), multidrug resistant Pseudomonas sp. and pan‐resistant NDM‐1‐containing Enterobacteriaceae, there is also conclusive evidence of the emergence and impact of resistance in equine patients . Hospitalisation and antimicrobial drug administration have been shown to increase resistance to antimicrobial agents and multidrug resistance of Escherichia coli in equine faeces as well as S. aureus on the skin of horses .…”

Section: National Research Council Operative Wound Classificationmentioning

confidence: 99%

Perioperative antimicrobials: Should we be concerned about antimicrobial drug use in equine surgical patients?

Southwood

2014

Equine Veterinary Journal

View full text Add to dashboard Cite

Multi-drug-resistantEnterococcusspp. as a cause of non-responsive septic synovitis in three horses

Abstract: Increased awareness of MDR pathogens in equine wound infections is essential. Prompt diagnostic testing, appropriate therapy, infection control strategies and on-going monitoring and management are vital to limit the clinical impact of these organisms.

Cited by 31 publications

References 44 publications

A retrospective analysis of antimicrobial resistance in bacterial pathogens in an equine hospital (2012–2015)

A retrospective analysis of antimicrobial resistance in bacterial pathogens in an equine hospital (2012–2015)

Gram-positive aerobic and microaerophilic microorganisms isolated from pathological processes and lesions of horses

Perioperative antimicrobials: Should we be concerned about antimicrobial drug use in equine surgical patients?

Contact Info

Product

Resources

About