Multi-drug resistant ESKAPE pathogens and the uses of plants as their antimicrobial agents

Synergistic action of 6-gingerol as an adjuvant to colistin for susceptibility enhancement in multidrug-resistant Klebsiella pneumoniae isolates

“…12 Phytochemicals are known to exert a direct antimicrobial effect and improve the efficacy of conventional antibiotics when used in combinations. 11,12 Furthermore, these plant-derived compounds can interact with critical stages of the pathogenic process, reducing the potential of bacteria to develop resistance. 12 Consequently, combining these compounds with conventional antibiotics seems promising by allowing their reutilization, which has lost effectiveness due to the overactivity of the efflux pump system in Gram-negative bacteria.…”

“…11,12 Furthermore, these plant-derived compounds can interact with critical stages of the pathogenic process, reducing the potential of bacteria to develop resistance. 12 Consequently, combining these compounds with conventional antibiotics seems promising by allowing their reutilization, which has lost effectiveness due to the overactivity of the efflux pump system in Gram-negative bacteria. 13,14 Therefore, restoring the sensitivity of bacteria to colistin using potential phytochemicals as an adjuvant could considerably improve therapeutic outcomes and may be a potential approach for treating infections caused by colistin-resistant MDR-KP.…”

“…13,14 Therefore, restoring the sensitivity of bacteria to colistin using potential phytochemicals as an adjuvant could considerably improve therapeutic outcomes and may be a potential approach for treating infections caused by colistin-resistant MDR-KP. 12…”

Evaluation of Antibacterial Efficacy of Centella asiatica-Mediated Selenium Oxide Nanoparticles Against Multidrug-Resistant Upper Respiratory Isolates

“…The emergence of new diseases and the virulence of the pathogens create fear because of the challenges in the treatment of diseases to find an effective cure [ 1 ]. Antibiotics have been discovered and utilized as treatments for various diseases caused by microbial pathogens.…”

A statistical approach to enhance the productivity of Streptomyces baarensis MH-133 for bioactive compounds

“…Researchers have implemented multiple emerging strategies to combat multidrug-resistant (MDR) ESKAPE pathogens. Researchers have investigated antibiotic combinations and adjuvants, bacteriophages, antimicrobial peptides, nanoparticles, and plant extracts as potential treatments for ESKAPE infections [ 7 ]. Actinomycetes, specifically Streptomyces , are a category of bacteria that have been linked to the production of many antibiotics used today [ 8 ].…”