Multi drug-resistance tuberculosis in Istanbul

Kılıçaslan, Zeki; Sarimurat, N; Ortakoylu, Gonenc; Kucuk, Celalettin; Arıcı, G; Caglar, Emel

doi:10.1016/0962-8479(94)90737-4

Cited by 2 publications

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“…As the rates in Istanbul were expected to be different from the rates in Turkey overall, the studies that were done in Istanbul were investigated. In a multi-center study from Istanbul involving 1,370 adult patients, the rate of resistance to at least one drug was found to be 24.8%, whereas the rate of resistance to INH was 12.5%, to RMP was 10%, to EMB was 4.4%, and to MDR was 6.7%; these rates were close to our results [20]. It can be concluded that anti-TB drug resistance rates are high in Istanbul.…”

Section: Discussionsupporting

confidence: 75%

Demographic and microbial characteristics and drug resistance of childhood tuberculosis in Istanbul: analysis of 1,541 cases

Çakır

Erdem

Özlü

et al. 2014

J Infect Dev Ctries

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Introduction: Although tuberculosis (TB) is frequently seen in Turkey, there are limited studies on childhood TB. We aimed to describe clinical and laboratory findings, including drug resistance, of children with TB in Istanbul, Turkey. Methodology: The study included all children aged 0-14 years who were registered in public dispensaries between 2006 and 2010. Results: The study included 1,541 cases. Forty-four percent (n = 763) of the patients were male with a mean age of 8.86±4.19 years. Fiftyfive percent of the patients had pulmonary TB, 39% had extrapulmonary TB, and 6% had both pulmonary and extrapulmonary TB. The most common extrapulmonary involvement sites were the pleura (n = 193), lymph nodes (n = 247), and central nervous system (n = 41). Forty-one percent of the patients were evaluated microbiologically and 35% of them were positive. For the total study group, 14% of them were positive. A drug susceptibility test was performed on 108 patients. Drug resistance to at least one drug was detected in 16% (n = 17), to isoniazid in 15% (n = 16), streptomycin in 12% (n = 12), rifampicin in 9% (n = 10), ethambutol in 7% (n = 8), and multi-drug resistance in 8% (n=9) of patients. Conclusions: This is the largest analysis on demographic features and drug resistance of childhood TB in Turkey. In Turkey, the rate of microbiological diagnosis is low, similar to rates worldwide. More microbiological studies and drug resistance tests should be done and annual changes should be followed with multi-center studies.

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Section: Discussionsupporting

confidence: 75%

Demographic and microbial characteristics and drug resistance of childhood tuberculosis in Istanbul: analysis of 1,541 cases

Çakır

Erdem

Özlü

et al. 2014

J Infect Dev Ctries

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“…In a recent study in Turkey, it was shown that primary resistance to INH and RIF is 8.6 and 5.6%, respectively, and acquired resistance is 25.3 and 26.5%, respectively, and the primary and secondary MDR rates were 3.1 and 18.5%, respectively (9). We conducted this study to determine drug resistance to anti-TB drugs among TB patients in the Duzce district in the northwest part of Turkey.…”

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confidence: 98%

The Resistance to Major Antituberculous Drugs of <i>Mycobacterium tuberculosis</i> Strains Isolated from the Respiratory System Specimens of Tuberculosis Patients in Duzce, Turkey

Ozturk,

Balbay,

Kaya

et al. 2005

Jpn J Infect Dis

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Though generally curable, tuberculosis (TB) is becoming increasingly resistant to commonly used antibiotics. Drug-resistant and multidrug-resistant (MDR)-TB is a consequence of monotherapy, insufficient drug therapy and national TB control programs. The present study was designed to reveal the resistance to major antimicrobial drugs (isoniazid [INH], streptomycin [SM], ethambutol [EMB], and rifampicin [RIF]) of Mycobacterium tuberculosis isolated from the respiratory specimens of TB patients in Duzce, Turkey. A total of 62 TB patients (46 male, 16 female; age: 17 -75 mean: 42 ± 15.9) were included in the study; 52 (83.8%) were new cases and susceptible to all anti-TB drugs, while 10 (16.2%) were previously treated cases. Antimicrobial susceptibility tests were performed by the proportion method in Löwenstein-Jensen medium. Fifty-two of the 62 (83.8%) isolated M. tuberculosis strains were found to be susceptible to all drugs, and 7 (11.3%), 5 (8%), and 3 (4.8%) were resistant to SM, INH, and RIF, respectively; 3 (4.8%) were MDR. There were no EMB-resistant strains. The results of this study show the presence of drug-resistant and MDR strains of TB at Duzce in the northwest part of Turkey.

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Multi drug-resistance tuberculosis in Istanbul

Cited by 2 publications

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Demographic and microbial characteristics and drug resistance of childhood tuberculosis in Istanbul: analysis of 1,541 cases

Demographic and microbial characteristics and drug resistance of childhood tuberculosis in Istanbul: analysis of 1,541 cases

The Resistance to Major Antituberculous Drugs of <i>Mycobacterium tuberculosis</i> Strains Isolated from the Respiratory System Specimens of Tuberculosis Patients in Duzce, Turkey

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