Multi-drug hybrid delivery systems with distinct release profiles based on gelatin/collagen containing vesicles derived from block copolymers

Gil, Viviane S. B.; Gil, Camila Silva Brey; Goulart, Gisele Assis Castro; Oréfice, Rodrigo Lambert

doi:10.1016/j.ijbiomac.2019.08.056

Cited by 13 publications

(3 citation statements)

References 27 publications

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where Q t is the amount of drug released at time t , Q 0 is the initial amount of drug in the solution, K 0 , K H , and K k are the constants of the equations, Q t /Q ∞ is the fraction of the drug released at time t , and η is the drug release exponent. Values of 0.45 ≤ η correspond to Fickian type diffusion mechanism, 0.45 < η > 0.89 to non-Fickian transport, η = 0.89 to Case II transport, and η > 0.89 to Super Case II transport [ 41 , 42 , 43 ]. The best-fitting model was identified according to the correlation coefficient (R 2 ).…”

Section: Methodsmentioning

confidence: 99%

Synthesis and Characterization of a pH- and Temperature-Sensitive Fe3O4-SiO2-Poly(NVCL-co-MAA) Nanocomposite for Controlled Delivery of Doxorubicin Anticancer Drug

et al. 2023

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This work reports the synthesis, characterization, and in vitro release studies of pH- and temperature-sensitive Fe3O4-SiO2-poly(NVCL-co-MAA) nanocomposite. Fe3O4 nanoparticles were prepared by chemical coprecipitation, coated with SiO2 by the Stöber method, and functionalized with vinyl groups. The copolymer poly(N-vinylcaprolactam-co-methacrylic acid) (poly(NVCL-co-MAA)) was grafted onto the functionalized Fe3O4-SiO2 nanoparticles by free radical polymerization. XRD, FTIR, TGA, VSM, and TEM techniques were performed to characterize the nanocomposite. The release behavior of Doxorubicin (DOX) loaded in the nanocomposite at pH 5.8 and 7.4, and two temperatures, 25 and 37 °C, was studied. According to the release studies, approximately 55% of DOX is released in 72 h at pH 7.4, regardless of temperature. At pH 5.8, 78% of DOX was released in 48 h at 25 °C, and when increasing the temperature to 37 °C, more than 95 % of DOX was released in 24 h. The DOX release data treated with Zero-order, first-order, Higuchi, and Korsmeyer–Peppas models showed that Higuchi’s model best fits the data, indicating that the DOX is released by diffusion. The findings suggest that the synthesized nanocomposite may be useful as a DOX carrier in biomedical applications.

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Section: Methodsmentioning

confidence: 99%

Synthesis and Characterization of a pH- and Temperature-Sensitive Fe3O4-SiO2-Poly(NVCL-co-MAA) Nanocomposite for Controlled Delivery of Doxorubicin Anticancer Drug

et al. 2023

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“…The vesicles were combined with free adapalene and silver sulfadiazine and incorporated into collagen and gelatin matrices. The created material was demonstrated to function as a skin dressing that combined a longer and slower release of adapalene to promote skin healing with a gradual release of significant amounts of medicines within the initial hours of use (to stop the growth of the infection) [108]. In another study, ionic medication (ionized cromoglicate sodium and ipratropium bromide) release via inhalable dry powders including gelatin was investigated.…”

Section: Collagen and Gelatinmentioning

confidence: 99%

An Overview of Biopolymers for Drug Delivery Applications

Opriș,

Mormile,

Lung

et al. 2024

Applied Sciences

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Nowadays, drug delivery has an important role in medical therapy. The use of biopolymers in developing drug delivery systems (DDSs) is increasingly attracting attention due to their remarkable and numerous advantages, in contrast to conventional polymers. Biopolymers have many advantages (biodegradability, biocompatibility, renewability, affordability, and availability), which are extremely important for developing materials with applications in the biomedical field. Additionally, biopolymers are appropriate when they improve functioning and have a number of positive effects on human life. Therefore, this review presents the most used biopolymers for biomedical applications, especially in drug delivery. In addition, by combining different biopolymers DDSs with tailored functional properties (e.g., physical properties, biodegradability) can be developed. This review summarizes and provides data on the progress of research on biopolymers (chitosan, alginate, starch, cellulose, albumin, silk fibroin, collagen, and gelatin) used in DDSs, their preparation, and mechanism of action.

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“…The polymeric nature of gelatin and its ability to bind various therapeutic compounds renders this collagen product an attractive carrier in many pharmaceutical applications. Moreover, gelatin is also applied as a gelling agent in food products [24][25][26][27][28].…”

Section: Applications Of Collagensmentioning

confidence: 99%

Three Decades of Research on Recombinant Collagens: Reinventing the Wheel or Developing New Biomedical Products?

Fertala

2020

Bioengineering

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Collagens provide the building blocks for diverse tissues and organs. Furthermore, these proteins act as signaling molecules that control cell behavior during organ development, growth, and repair. Their long half-life, mechanical strength, ability to assemble into fibrils and networks, biocompatibility, and abundance from readily available discarded animal tissues make collagens an attractive material in biomedicine, drug and food industries, and cosmetic products. About three decades ago, pioneering experiments led to recombinant human collagens’ expression, thereby initiating studies on the potential use of these proteins as substitutes for the animal-derived collagens. Since then, scientists have utilized various systems to produce native-like recombinant collagens and their fragments. They also tested these collagens as materials to repair tissues, deliver drugs, and serve as therapeutics. Although many tests demonstrated that recombinant collagens perform as well as their native counterparts, the recombinant collagen technology has not yet been adopted by the biomedical, pharmaceutical, or food industry. This paper highlights recent technologies to produce and utilize recombinant collagens, and it contemplates their prospects and limitations.

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Multi-drug hybrid delivery systems with distinct release profiles based on gelatin/collagen containing vesicles derived from block copolymers

Cited by 13 publications

References 27 publications

Synthesis and Characterization of a pH- and Temperature-Sensitive Fe3O4-SiO2-Poly(NVCL-co-MAA) Nanocomposite for Controlled Delivery of Doxorubicin Anticancer Drug

Synthesis and Characterization of a pH- and Temperature-Sensitive Fe3O4-SiO2-Poly(NVCL-co-MAA) Nanocomposite for Controlled Delivery of Doxorubicin Anticancer Drug

An Overview of Biopolymers for Drug Delivery Applications

Three Decades of Research on Recombinant Collagens: Reinventing the Wheel or Developing New Biomedical Products?

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