Multi–Detector Row Helical CT in Preoperative Assessment of Small (≤1.5 cm) Liver Metastases: Is Thinner Collimation Better?

Haider, Masoom A.; Amitai, Michal Marianne; Rappaport, Daniel C.; O’Malley, Martin; Hanbidge, Anthony; Redston, Mark; Lockwood, Gina; Gallinger, Steven

doi:10.1148/radiol.2251011225

Cited by 116 publications

(49 citation statements)

References 24 publications

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“…They then compared reconstructed images at collimation of 5, 3.75 and 2.5 mm with 50% overlap. They did not obtain an improved sensitivity in the detection of small hepatic metastases with reconstructed images at collimation less than 5 mm [26]. When we used 5 mm reconstructed slice thickness, we observed that similar results were obtained with mm per rotation.…”

Section: Discussionsupporting

confidence: 60%

Detection of liver metastases under 2 cm: comparison of different acquisition protocols in four row multidetector-CT (MDCT)

et al. 2005

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This study compared different acquisition protocols performance to detect small liver metastases (<2 cm). Thirty consecutive patients with histologically proven hepatic metastases were explored by MDCT at the liver equilibrium phase by four successive acquisitions. We compared the following protocols (1-4): 5/30/1.5 (section thickness/table speed/pitch); 5/15/0.75; 5/11.25/0.75; and 2.5/15/1.5 with the same X-ray dose. The gold standard was based on patient radiological follow-up. Evolutive lesions were considered as true positive (TP). The described lesions, not found on the follow-up exams despite tumoral progression, were considered as false positive (FP). Stable lesions could not be considered as metastasis and were eliminated. One hundred and seventy-six lesions were detected: 61 TP and 91 FP. Twenty-four lesions were eliminated.The mean kappa values for protocols 1, 2, 3 and 4 were, respectively, 0.43, 0.68, 0.73 and 0.51 (0.61-0.80: substantial agreement) and the mean areas under the ROC curve were, respectively, 0.76, 0.87, 0.86 and 0.80. The results of protocols 2 and 3 were significantly superior to those of protocols 1 and 4. MDCT protocols using thin sections or an increased table speed are less efficient in detecting small metastases.

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Section: Discussionsupporting

confidence: 60%

Detection of liver metastases under 2 cm: comparison of different acquisition protocols in four row multidetector-CT (MDCT)

et al. 2005

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“…Past publications have been quite restricted here and recommended that the slice thickness should not be ! 5 mm for the low-contrast organ liver [8,9] . Recent publications, however, disocvered advantages for a reconstructed slice thickness down to 3 mm [10] .…”

Section: Computed Tomographymentioning

confidence: 99%

Imaging of Hepatocellular Carcinoma by Computed Tomography and Magnetic Resonance Imaging: State of the Art

Zech

Reiser

Herrmann³

2009

Dig Dis

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Hepatocellular carcinoma (HCC) is a very frequent tumor worldwide. Its incidence is linked to the distribution of liver cirrhosis and viral hepatitis, which are the main risk factors for the development of HCC. For the evaluation of the cirrhotic liver and for the diagnosis of HCC, multidetector computed tomography (MDCT) proved to be a robust and reliable tool. In MDCT the diagnosis of HCC can be made based on neovascularization with increased arterial and decreased portal venous supply. With modern magnetic resonance imaging (MRI), spatial resolution and robustness increased dramatically. Beside the evaluation of neovascularization by means of gadolinium-enhanced early dynamic MRI, the main advantages of MRI are additional information on tissue composition and liver-specific function. With diffusion-weighted imaging or plain T₁- and T₂-weighted sequences, different tissue elements like fat, hemorrhage, glycogen, edema and cellular density can be evaluated. Liver-specific contrast agents give insight into the Kupffer cell density or the hepatocellular function. The integration of all these parts into the MR examination allows for a very high detection rate for overt HCC nowadays, although very small HCCs are still a challenge. Moreover, insight into the different stages of hepatocarcinogenesis can be possible with MRI. Despite its limited availability in some countries, it has to be rendered to be the modality of choice for the distinct evaluation of the cirrhotic liver.

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“…From the viewpoint of hemodynamics, few HCCs ≤5 mm in diameter exhibit hypervascularity during the course of their growth, except for intrahepatic metastases, and collimation at 5 mm is therefore considered appropriate for screening [32]. …”

Section: Improvements On Ctmentioning

confidence: 99%

Diagnostic Imaging of Hepatocellular Carcinoma: Recent Progress

Kudo

2011

Oncology

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The diagnostic imaging of hepatocellular carcinoma (HCC) has recently undergone marked progress. The advent of the ultrasound (US) contrast agent Sonazoid, approved in January 2007, and magnetic resonance imaging (MRI) with the liver-specific MRI contrast agent gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA-MRI), approved in January 2008, are of particular significance. Sonazoid contrast-enhanced US (Sonazoid-CEUS) is useful not only for the diagnosis of HCC, but also for guiding treatment and assessing treatment response. Sonazoid-CEUS has proven to be particularly effective for screening and staging, which used to be considered impossible with CEUS, through the introduction of the newly developed diagnostic technique of defect reperfusion imaging. It is still not possible if other vascular agents such as SonoVue and Definity are used. In particular, Gd–EOB-DTPA-MRI has been suggested to be much more reliable in the differentiation of early HCC from precancerous dysplastic nodules than any other modalities such as multidetector raw computed tomography, dynamic MRI, and superparamagnetic iron oxide-MRI. A decrease in contrast uptake in the hepatocyte phase observed on EOB-MRI is strongly suggestive of cancer, and the absence of early staining in the arterial phase suggests early HCC. The differential diagnostic capacity of Gd-EOB-DTPA-MRI is considered to far exceed that of what were previously the most useful imaging techniques, computed tomography (CT) during hepatic arteriography or CT during arterial portography, and to be comparable to that of the pathological diagnosis by pathologists specialized in liver.

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Multi–Detector Row Helical CT in Preoperative Assessment of Small (≤1.5 cm) Liver Metastases: Is Thinner Collimation Better?

Abstract: Image reconstruction with multi-detector row helical CT at collimations less than 5 mm may not improve sensitivity in the detection of hepatic metastases 1.5 cm or smaller.

Cited by 116 publications

References 24 publications

Detection of liver metastases under 2 cm: comparison of different acquisition protocols in four row multidetector-CT (MDCT)

Detection of liver metastases under 2 cm: comparison of different acquisition protocols in four row multidetector-CT (MDCT)

Imaging of Hepatocellular Carcinoma by Computed Tomography and Magnetic Resonance Imaging: State of the Art

Diagnostic Imaging of Hepatocellular Carcinoma: Recent Progress

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