Multi-component synthesis of highly substituted imidazoles catalyzed by nanorod vanadatesulfuric acid

Abstract

Nanorod vanadatesulfuric acid (VSA NRs), as a recyclable and eco-benign catalyst, was used for one-pot synthesis of 2,4,5-trisubstituted imidazoles and 1,2,4,5-tetrasubstituted imidazoles using aldehydes, benzil, benzoin or 9,10-phenanthrenequinone and ammonium acetate or aniline under solvent-free conditions providing high to excellent yields. VSA is easily prepared by a simple reaction of chlorosulfonic acid and sodium metavanadate in high purity. As compared with the conventional procedures, the present protocol offers several advantages such as simplicity of procedure, short reaction time, high yields, easy workup, recoverability and reusability of the catalyst and simple purification of the products.

One Pot Multicomponent Green Synthesis of Triaryl Imidazoles Catalysed by Nano Nickel Cobalt Ferrite

“…Poly substituted imidazoles were first synthesised in 1882 by using an aldehyde with 1, 2-dicarbonyl compound and ammonia (Radziszewski 1882) 15 . Afterwards, various methods have been developed for the synthesis of 2,4,5-trisustituted imidazoles by using various catalysts such 16 as Al…”

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“…Imidazole and its derivatives are the biologically active compounds with antidepressant [16], anti-inflammatory [17], antiviral [18], herbicidal [19], anti-cancer [20], analgesic [21], antitubercular [22] antifungal [23], and antiallergic effects [24]. The fivemembered imidazole structure exists in a variety of biologically important structures such as histidine amino acid [25] and histamine hormone [26].…”

An efficient method for the synthesis of 2,4,5-trisubstituted imidazoles using lactic acid as promoter

“…Various methods are reported in the literature for the one-pot synthesis of imidazole derivatives from benzil, aromatic aldehyde, and ammonium acetate. [21], nanorod vanadate sulfuric acid [22], magnetic Fe 3 O 4 [23], etc.) are reported for imidazole synthesis.…”