Multi-component syntheses of heterocycles by transition-metal catalysis

D’Souza, Daniel M.; Müller, Thomas J. J.

doi:10.1039/b608235c

Cited by 982 publications

(240 citation statements)

References 90 publications

(42 reference statements)

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“…[144][145][146][147][148] The indole nucleus appears in many important compounds and a number of palladium-based methods have been disclosed for its synthesis and functionalization. [149] The introduction of highly reactive dialkylbiaryl phosphine palladium complexes, however, has allowed some significant new protocols to be developed.…”

Section: Applications In the Construction Of Heterocyclesmentioning

confidence: 99%

Biaryl Phosphane Ligands in Palladium‐Catalyzed Amination

2008

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Palladium-catalyzed amination of aryl halides has undergone rapid development in the last 12 years. This has been largely driven by implementation of new classes of ligands. Biaryl phosphines have proven to provide especially active catalysts in this context. This review discusses the applications that these catalysts have found in C-N cross-coupling in heterocycle synthesis, pharmaceuticals, materials science and natural product synthesis.

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Section: Applications In the Construction Of Heterocyclesmentioning

confidence: 99%

Biaryl Phosphane Ligands in Palladium‐Catalyzed Amination

2008

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“…The advantages of hemin over inorganic metal catalysts include higher selectivity, lower cost, and higher surface activity (D'Souza and Muller 2007). Its activity is similar to that of the peroxidase enzyme (Guo et al 2011), and it exhibits good electro catalysis based on the reversible redox of Fe(III)/Fe(II) (Kong et al 2015).…”

Section: Introductionmentioning

confidence: 99%

Graphene/Hemin Hybrid Material as a Catalyst for Degradation of Alkaline Lignin with Hydrogen Peroxide

Chen

Yan

2017

BioResources

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A graphene/hemin (H-GN) catalyst for lignin degradation was prepared by a wetchemistry method with graphene oxide and hemin. Hemin was absorbed onto the graphene surface through π-π interaction. Graphene served as a supporting material for hemin, providing a large contact area between the active molecules of catalyst and substrate, as well as protecting hemin from self-oxidation and maintaining its active molecules. The H-GN catalyst showed high catalytic efficiency in the degradation of alkaline lignin under gentle conditions. At pH 13.0, the degradation rate was 49.7% with H-GN and H2O2 (mass ratio of H2O2 to lignin of 10:1) under 60 °C, which was higher than 34.9% for non-catalyst degradation. At pH 13.2, it was as high as 92.9 wt.% at 100 °C. The lignin was decomposed into small molecules with styrene as the main final product below pH 13 and with the major products of 4-hydroxy-4-methyl-2-pentanone and bis(2-ethylhexyl) phthalate at pH 13.2.

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“…Multi component reactions (MCRs) have more importance, great interest enjoying an outstanding status in modern organic synthesis and medicinal chemistry because they are one-pot processes bringing together three or more components and show high atom economy and high selectivity 1,2 . MCRs comply with the principles of green chemistry in terms of economy of steps as well as many of the rigid criteria of an ideal organic synthesis.…”

Section: Introductionmentioning

confidence: 99%

“…In the initial step, oxiindole [1] was synthesized by reaction of isatin with hydrazine hydrate in reflux temperature for 3 hr. The pyrano [2,3- Several methods are used in the synthesis of these pyrano [2,3-b]indoles derivatives.…”

Section: Chemistrymentioning

confidence: 99%