Multi-component solvent-free cascade reaction of 2-cyanoacetamides: regioselective synthesis of pyridin-2-ones bearing quaternary centers

Abstract

A novel protocol has been constructed for the synthesis of four types of pyridin-2-ones via multicomponent solvent-free cascade reactions of 2-cyanoacetamides, various ketones, and acetone.

Solubility Determination, Solvent Effect, Thermodynamic Modeling, and Preferential Solvation of 2-Cyanoacetamide in Four Aqueous Binary Mixtures of Alcohols

“…7,8 2-Cyanoacetamide may be employed in the spectrofluorimetric technique to measure antihistaminic H1 receptor antagonist medications, including fexofenadine hydrochloride, cetirizine dihydrochloride, and ebastine. 1,3,9,10 A fundamental understanding of solid−liquid phase equilibrium and critical thermodynamic data, especially solubility, is crucial to improve the design and control of the crystallization process. As a physiochemical characteristic, solubility is essential to determining how active pharmaceutical ingredients (APIs) balance out in solid−liquid combinations.…”

“…It is expressed as C 3 H 4 N 2 O. This substance has potential uses in a range of fields, including medicinal chemistry and organic synthesis. − 2-Cyanoacetamide can be used as a reagent in specific reactions or as a starting material to synthesize other biological compounds by scientists and chemists. , It is crucial to handle these substances carefully and take the necessary safety measures at all times. , 2-Cyanoacetamide may be employed in the spectrofluorimetric technique to measure antihistaminic H1 receptor antagonist medications, including fexofenadine hydrochloride, cetirizine dihydrochloride, and ebastine. ,,, A fundamental understanding of solid–liquid phase equilibrium and critical thermodynamic data, especially solubility, is crucial to improve the design and control of the crystallization process. As a physiochemical characteristic, solubility is essential to determining how active pharmaceutical ingredients (APIs) balance out in solid–liquid combinations. , …”

An Environmentally Benign Multicomponent Cascade Reaction of 3-Formylchromones, 2-Naphthols, and Heterocyclic Ketal Aminals: Site-Selective Synthesis of Functionalized Morphan Derivatives

“…Green chemistry is the application of chemical knowledge, chemical technology, and chemical methods to all chemicals and chemical processes to reduce the use of chemical reaction materials that are harmful to human health and the environment and to make full and reasonable use of resources that can be adapted and sustainably developed . The use of environmentally friendly solvents such as water, ionic liquids, supercritical CO 2 , and propylene carbonate (PC), as well as solvent-free reactions instead of traditional organic solvents in chemical reactions, is a crucial aspect of green chemistry …”

Direct Use of Benzylic Alcohols for Multicomponent Synthesis of 2‐Aryl Quinazolinones Utilizing the π‐Benzylpalladium(II) System in Water

“…Multicomponent reactions (MCRs) are recognized as an atom-economic synthetic strategy allowing the straightforward and efficient transformation of novel fine chemicals directly from easily available starting materials. [1] This system has many advantages such as high atom economy and less waste generation compared to stepwise reactions involving multistep and hazardous processes. The first report of MCRs was in 1850 by Strecker, in the well-known Strecker reaction, for the synthesis of α-amino acids using aldehydes, hydrogen cyanide and ammonia as substrates.…”