Multi-component reactions between 2-aminopyrimidine, aldehydes and isonitriles: the use of a nonpolar solvent suppresses formation of multiple products

Synthesis and Characterization of Imidazo[1,2-a]pyridines and Zolimidine

“…It has also been performed using a nonpolar solvent [13], or in the presence of an ionic liquid [14]. In recent years several improved conditions have been reported [15].…”

Recent progress of Ammonium chloride as catalyst in organic synthesis

“…Parchinsky et al 16 reported that various novel imidazo[1,2-a]pyrimidines 28 were synthesized in 49-60% yield via a multicomponent reaction of 2-aminopyrimidine, aromatic aldehyde, and isonitrile in presence of…”

Insights into the N,N-diacylation reaction of 2-aminopyrimidines and deactivated anilines: an alternative N-monoacylation reaction

“…The acylation of 2-aminopyrimidines or 2-amino-N-heterocycles has, in some cases, been accompanied by the cyclocondensation of the resulting acyl derivatives, 21,26 as a result of the interaction between the peripheral group and one of the nitrogen atoms of the ring. Reacting with aldehydes 2-aminopyrimidine scaffold plays a dual role by providing a nucleophilic amino group to form a Schiff base and/or a ring nitrogen to form adducts.…”