Under the background of artificial intelligence (AI), a human resource information management system was designed to facilitate hospital human resource management and improve hospital management efficiency. Based on AI, SOA was constructed and Java2 platform enterprise edition (J2EE) was combined with Java to design and research hospital human resource information management system. In addition, the function and performance required by the system were tested. The results showed that the designed system showed high safety in requirement analysis and performance. The function focused mainly on the systematic analysis of personnel management, recruitment management, organization and personnel management, and patient medical information. The constructed system could work normally and achieve the efficiency of hospital human resource management. The evaluation response time of system home page access was less than 1 second when 300 users were concurrent, and the utilization rate of service CPU was lower than 50% without abnormal memory fluctuation. The concurrent response time of all 20 managers online was less than 5 seconds, and the utilization rate of the service was lower than 70%. When the information of 100 employees in the system was queried concurrently, the average CPU utilization of the database server exceeded 90%. After performance optimization, the test result showed that the transaction response time was reduced to 0.23 seconds, which met the target requirement. In conclusion, the proposed intelligent human resource management system could reduce hospital management cost and the high sharing of human resource information provided a reference for the decision-making system of hospital leaders.