Multi‐channel near‐infrared spectroscopy shows reduced activation in the prefrontal cortex during facial expression processing in pervasive developmental disorder

Nakadoi, Yoshihiro; Sumitani, Satsuki; Watanabe, Yukina; Akiyama, Mai; Yamashita, Naomi; Ohmori, Tetsuro

doi:10.1111/j.1440-1819.2011.02290.x

Cited by 16 publications

(8 citation statements)

References 32 publications

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“…The students with presenteeism did not show significant increases in prefrontal cortex activation during the WFT and TMT tasks, whereas healthy controls did. Previous studies reported that healthy controls had a greater increase in oxy-Hb under various cognitive stimulations in prefrontal cortex compared to patients with depression [22] [23], schizophrenia [24], and pervasive developmental disorder [25] [26]. Our results are quite similar to these previous studies.…”

Section: Discussionsupporting

confidence: 91%

Investigation of Prefrontal Cortex Activity in University Students with Presenteeism: A Near-Infrared Spectroscopy (NIRS) Study

Matsushita¹,

Yamamura²,

Ikeda³

2015

JBBS

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Presenteeism refers to impaired performance attributed to attending work with health problems. There has been no study examining the state of presenteeism with objective measures. We compared cerebral hemodynamic changes, measured by near-infrared spectroscopy (NIRS), during neuropsychological tests conducted by university students with presenteeism and healthy controls. Twenty-two university students participated in the study; 11 of them with impaired performance caused by mental health problem were allocated to the presenteeism group and 11 without health problems to the control group. Presenteeism was assessed by the Presenteeism Scale for Students. To evoke hemodynamics changes, the participants completed a Word Fluency Test (WFT) and a Trail Making Test (TMT). The NIRS probes were located over the bilateral prefrontal area. Students with presenteeism had significantly higher incidences of depression than controls. However, there was no significant difference in behavioral performance examinations between the two groups. With regard to hemodynamics changes, the repeated measures analysis of covariance of the NIRS signals revealed significant interactions between group and task activation. Although we observed a significant increase in oxygenated hemoglobin concentration during the WFT among controls (simple main effect; left channel, F(1, 19) = 27.34, P < 0.001; right channel, F(1, 19) = 22.05, P < 0.001), no changes were found in students with presenteeism during either the WFT (simple main effect; left channel, F(1, 19) = 0.12, P < 0.732; right channel, F(1, 19) = 0.08, P < 0.778) or TMT tasks (left channel, t = −0.94, P with Bonferroni correction = 0.745; right channel, t = −2.19, P with Bonferroni correction < 0.113). This is the first study to reveal differences in activity in the cerebral cortex associated with presenteeism. The fact that students with presenteeism have prefrontal dysfunction might reinforce the concept of presenteeism.

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Section: Discussionsupporting

confidence: 91%

Investigation of Prefrontal Cortex Activity in University Students with Presenteeism: A Near-Infrared Spectroscopy (NIRS) Study

Matsushita¹,

Yamamura²,

Ikeda³

2015

JBBS

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“…This weaker response was related to more difficulty in recognising these expressions. The impairment was milder but qualitatively similar to the findings from the clinical group (Nakadoi et al, 2012), thereby supporting the existence of a broad autism spectrum.…”

Section: Introductionsupporting

confidence: 74%

Spontaneous resting‐state gamma oscillations are not predictive of autistic traits in the general population

Groot

Strien

2018

Eur J of Neuroscience

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The autism spectrum hypothesis states that not only diagnosed individuals but also individuals from the general population exhibit a certain amount of autistic traits. While this idea is supported by neuroimaging studies, there have been few electrophysiological studies. In particular, there have been no spontaneous resting‐state studies yet. In order to examine the autism spectrum hypothesis, the present study tried to predict the level of autistic traits typically developing young adults (n = 93) exhibit from spontaneous resting‐state gamma power, a measure that has been linked to social functioning impairments seen in autism. The influence of age and gender was controlled for by employing regression. It was expected that enhanced gamma activity would be predictive of self‐reported autistic traits. The model with only age and gender included reached significance, with higher age within this student population being related to more autistic traits. However, no relationship between either low (30–50 Hz) or high (50–70 Hz) gamma power and autistic traits was found. Models with eyes closed low gamma asymmetry and eyes closed high gamma asymmetry included did reach significance, but these findings were not robust, and the gamma asymmetry explained very little additional variance above age and gender. In addition, exploratory correlation analyses showed no relationship between the other power spectra (delta, theta, alpha and beta) on the one hand and autistic traits on the other hand, suggesting that any relationship between spontaneous resting‐state brain electrophysiology and autistic traits might not be strong enough to be detected in the general population.

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“…NIRS measurements were performed as in our previous studies. 25 , 26 The 24 probes and four areas are shown in Figure 1 .…”

Section: Methodsmentioning

confidence: 99%

Prefrontal cortex activation during neuropsychological tasks might predict response to pharmacotherapy in patients with obsessive–compulsive disorder

Takeda

Sumitani

Hamatani

et al. 2017

NDT

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ObjectiveWe investigated oxyhemoglobin change in the prefrontal cortex (PFC) of patients with obsessive–compulsive disorder (OCD) who showed different responses to pharmacotherapy during neuropsychological tasks with near-infrared spectroscopy.Subjects and methodsA total of 42 patients with OCD (mean age: 35.6±9.6 years, 14 men, 28 women) and healthy control subjects (mean age: 35.4±9.7 years, 13 men, 29 women) were selected. Patients with OCD were divided into three groups (responders to selective serotonin-reuptake inhibitors (SSRIs), responders to SSRIs with antipsychotics, and nonresponders to SSRIs and SSRIs with antipsychotics) based on pharmacological response. We investigated oxyhemoglobin change in the PFC of subjects during Stroop tasks and a verbal fluency test with near-infrared spectroscopy.ResultsResponders to SSRIs showed smaller activation compared to control subjects during the Stroop incongruent task and verbal fluency test, but not during the Stroop congruent task. In contrast, responders to SSRIs with antipsychotics showed smaller activation compared to control subjects during all three tasks.ConclusionOur results suggest that activation of the PFC during Stroop tasks might predict responses to pharmacotherapy of patients with OCD.

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Multi‐channel near‐infrared spectroscopy shows reduced activation in the prefrontal cortex during facial expression processing in pervasive developmental disorder

Cited by 16 publications

References 32 publications

Investigation of Prefrontal Cortex Activity in University Students with Presenteeism: A Near-Infrared Spectroscopy (NIRS) Study

Investigation of Prefrontal Cortex Activity in University Students with Presenteeism: A Near-Infrared Spectroscopy (NIRS) Study

Spontaneous resting‐state gamma oscillations are not predictive of autistic traits in the general population

Prefrontal cortex activation during neuropsychological tasks might predict response to pharmacotherapy in patients with obsessive–compulsive disorder

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Multi‐channel near‐infrared spectroscopy shows reduced activation in the prefrontal cortex during facial expression processing in pervasive developmental disorder

Cited by 16 publications

References 32 publications

Investigation of Prefrontal Cortex Activity in University Students with Presenteeism: A Near-Infrared Spectroscopy (NIRS) Study

Investigation of Prefrontal Cortex Activity in University Students with Presenteeism: A Near-Infrared Spectroscopy (NIRS) Study

Spontaneous resting‐state gamma oscillations are not predictive of autistic traits in the general population

Prefrontal cortex activation during neuropsychological tasks might predict response to pharmacotherapy in patients with obsessive&ndash;compulsive disorder

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Prefrontal cortex activation during neuropsychological tasks might predict response to pharmacotherapy in patients with obsessive–compulsive disorder