Multi-centre field evaluation of the performance of the Trinity Biotech Uni-Gold HIV 1/2 rapid test as a first-line screening assay for gay and bisexual men compared with 4th generation laboratory immunoassays

Keen, Phillip; Conway, Damian P.; Cunningham, Philip; McNulty, Anna; Couldwell, Deborah L.; Davies, Stephen; Smith, Don; Gray, James; Holt, Martin; O’Connor, Catherine; Read, Phillip; Callander, Denton; Prestage, Garrett; Guy, Rebecca

doi:10.1016/j.jcv.2016.11.006

Cited by 9 publications

(10 citation statements)

References 24 publications

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“…19,20 In a recent study of HIV POCTs among sexual health services in NSW, 39% of all newly detected infections were classified as acute. 13 We agree that HIV POCTs should not be used as standalone screening tests when patients might have acute or recent HIV infection. 11,13,21 Also, such high-risk men require frequent testing for syphilis, 22 best performed on serum.…”

Section: Discussionmentioning

confidence: 97%

“…HIV POCTs have good accuracy in detecting chronic HIV infection, but their sensitivity can be as low as 57% in detection of acute HIV infection compared with fourth-generation immunoassay. 11,13 This becomes important for clinical services such as sexual health clinics, which are targeting and prioritising GBM with high-risk behaviour for frequent HIV testing, with the aim of diagnosing HIV as early as possible. 19,20 In a recent study of HIV POCTs among sexual health services in NSW, 39% of all newly detected infections were classified as acute.…”

Section: Discussionmentioning

confidence: 99%

“…6 Also, HIV POCTs when used as standalone screening tests, have lower sensitivity in detecting recently acquired infection, compared with gold-standard fourth-generation enzyme-linked immunosorbent assays (ELISAs) performed on serum. 11,13 The popularity of text messaging (short message service [SMS]) has been seen as it is used by the health sector to convey short communication to patients, especially reminders for appointments. In Sydney, a survey at a large sexual health service indicated that delivery of test results by SMS would be as acceptable as receiving results by telephone or in-person.…”

Section: Introductionmentioning

confidence: 99%

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Providing HIV results via SMS one day after testing: more popular than rapid point-of-care tests

et al. 2016

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An inner Sydney sexual health service introduced the option to gay and bisexual men of receiving a negative HIV result by SMS to mobile phone one business day after venipuncture (rapid SMS). Men could also choose one of the other options: a point-of-care-test (POCT), by phone, or in-person (clinicians could also require in-person). We followed-up patients choosing the rapid SMS method to ascertain their satisfaction. During 12 months, 473 men had 591 HIV tests. Of these tests, 5.4% were POCTs, 9.1% were in-person, 24% were by phone, and 62% were rapid SMS. HIV POCTs declined from being 22% of result methods in the pre-study period to 5.4% during the rapid SMS intervention period (odds ratio 0.20, 95% CI 0.13-0.32, P < 0.0001). Phone/in-person results declined from 78% to 33% (odds ratio 0.14, 95% CI 0.10-0.20, P < 0.0001). SMS was sent by the next business day in 95% of cases; 96% of men were satisfied; and 95% would choose this method for their next test. Of 77 men who previously had an HIV POCT, 56 (73%) elected a rapid SMS result rather than having another POCT. The higher accuracy of conventional serology was commonly expressed as the reason for choosing rapid SMS for results.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Providing HIV results via SMS one day after testing: more popular than rapid point-of-care tests

et al. 2016

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“…In the context of restricted Federal funding and increased prevention efforts, a number of Australian jurisdictions provided funding for HIV RPOC testing services for GBM [ 21 – 23 ]. RPOC testing is currently offered within clinical services (as user-pays models), and in stand-alone fixed site and outreach/pop-up community services funded by jurisdictional governments, with services delivered ranging from comprehensive primary healthcare to stand-alone HIV RPOC tests.…”

Section: Introductionmentioning

confidence: 99%

Trial and error: evaluating and refining a community model of HIV testing in Australia

Ryan

Pedrana

Leitinger³

et al. 2017

BMC Health Serv Res

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BackgroundThe 2012 regulatory approval of HIV rapid point of care (RPOC) tests in Australia and a national strategic focus on HIV testing provided a catalyst for implementation of non-clinical HIV testing service models. PRONTO! opened in 2013 as a two-year trial delivering peer-led community-based HIV RPOC tests targeting gay, bisexual and other men who have sex with men (GBM), with the aim of increasing HIV testing frequency. Initial data suggested this aim was not achieved and, as part of a broader service evaluation, we sought to explore client acceptability and barriers to testing at PRONTO! to refine the service model.MethodsWe present descriptive and thematic analyses of data from two in-depth evaluation surveys and four focus groups with PRONTO! clients focused on service acceptability, client testing history, intentions to test and barriers to testing for HIV and other sexually transmitted infections (STIs).ResultsThe three novel aspects of the PRONTO! model, testing environment, rapid-testing, peer-staff, were reported to be highly acceptable among survey and focus group participants. Focus group discussions revealed that the PRONTO! model reduced anxiety associated with HIV testing and created a comfortable environment conducive to discussing sexual risk and health. However, an absence of STI testing at PRONTO!, driven by restrictions on medical subsidies for STI testing and limited funds available at the service level created a barrier to HIV testing. An overwhelming majority of PRONTO! clients reported usually testing for STIs alongside HIV and most reported plans to seek STI testing after testing for HIV at PRONTO!. When deciding where, when and what to test for, clients reported balancing convenience and relative risk and consequences for each infection as guiding their decision-making.ConclusionsA community-based and peer-led HIV testing model reduced previously reported barriers to HIV testing, while introducing new barriers. The absence of STI testing at PRONTO! and the need to access multiple services for comprehensive sexual health screening, created a significant service engagement barrier for some clients. Understanding client motivations to access testing and ensuring novel service models meet client needs is crucial for developing acceptable sexual health services for high-risk populations.

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“…HIV testing is typically offered in four health service types in Australia: primary care (general practice), tertiary care (hospitals), sexual health centres and, more recently, community‐based (non‐clinical) HIV testing services. These service types differ in the source of funding (federal, jurisdictional, client co‐pay), staffing (medical doctors, nurses, peers) and tests offered (conventional serology, rapid point‐of‐care (RPOC) tests) 2–5 . It was not until 2011 that regulatory changes in Australia permitted the use of RPOC tests and testing outside clinical settings 6 .…”

mentioning

confidence: 99%

A comparative, retrospective analysis of HIV testing among gay, bisexual and other men who have sex with men in Melbourne, Australia

Ryan

Wilkinson

Chow

et al. 2019

Australian and New Zealand Journal of Public Health

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Objective: PRONTO!, a peer‐led rapid HIV‐testing service in Melbourne, Australia, opened to improve HIV testing among gay and bisexual men (GBM). We compared client characteristics and return testing among GBM testing at PRONTO! with GBM testing at Melbourne Sexual Health Centre (MSHC). Methods: All GBM attending PRONTO! and MSHC for HIV testing between August 2013 and April 2016 were included. We describe the number of tests, percentage of clients who returned during follow‐up, the mean number of tests and median time between tests at the two services. Results: At PRONTO!, 33% of 3,102 GBM and at MSHC 50% of 9,836 GBM returned for a further HIV test at least once. The mean number of tests per client was 1.7 and 2.5 at PRONTO! and MSHC (p<0.01), respectively. A majority of clients at both services reported behaviours that would recommend up to quarterly testing, however, the median time between tests was 20.0 and 17.0 weeks at PRONTO! and MSHC (p<0.01), respectively. Conclusions: A greater proportion of clients returned and returned frequently at MSHC compared to PRONTO!, however, at both services HIV testing frequency was suboptimal. Implications for public health: Novel HIV testing services should provide convenient and comprehensive sexual health services.

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Multi-centre field evaluation of the performance of the Trinity Biotech Uni-Gold HIV 1/2 rapid test as a first-line screening assay for gay and bisexual men compared with 4th generation laboratory immunoassays

Cited by 9 publications

References 24 publications

Providing HIV results via SMS one day after testing: more popular than rapid point-of-care tests

Providing HIV results via SMS one day after testing: more popular than rapid point-of-care tests

Trial and error: evaluating and refining a community model of HIV testing in Australia

A comparative, retrospective analysis of HIV testing among gay, bisexual and other men who have sex with men in Melbourne, Australia

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