Multi-Center Study of Early Lactate Clearance as a Determinant of Survival in Patients with Presumed Sepsis

Serum Lactate Albumin Ratio as a Predictor of Mortality in Severe Sepsis and Septic Shock at Tribhuwan University Teaching Hospital, Kathmandu

“…28 day mortality was 143 (59.6 %). It shows that in every two pa ent diagnosed as severe sepsis and sep c shock one will die, similar results 24 were found by study done by Chris an brun et al The single lactate value as a predic on of mortality in severe sepsis and sep c shock is controversial as it may increase in non pathological condi on for instance as a result of a high adrenaline level or alcohol intake and several studies were [25][26][27][28] not able to show lactate as predic ve value of mortality. APACHE II scoring system were used widely to assess out come in severe sepsis and sep c shock but this is me consuming, expensive and lengthy process having mul ple variables to calculate, so it is very imprac cal to use APACHE II scoring system in busy emergency room.…”

Febrile neutropenia in French emergency departments: results of an analysis of practice in a prospective multicentre survey

“…La mise en place de recommandations par la Surviving Sepsis Campaign a permis d'améliorer la détection des infections graves, mais 61,5 % des patients restent insuffisamment traités en raison d'une évaluation incorrecte. Le dosage de lactatémie a été recommandé pour permettre d'aider les médecins à repérer [20] et prendre en charge les infections graves [22]. Or, nous avons constaté dans notre étude que la lactatémie n'était pas souvent dosée.…”

“…Par conséquent, les procédures permettant d'optimiser la détection des infections graves n'ont été que partiellement appliquées pour cette population dont les signes de sévérité cliniques n'ont pas été reconnus. Toutes les études s'accordent donc à souligner l'importance d'un diagnostic précoce de ces états septiques graves, d'une prise en charge rapide et adaptée de ces patients et d'un transfert en unité de soins intensifs sans délai, quand il est possible [22]. Le pronostic des patients avec une infection grave repose donc sur leur prise en charge initiale [23].…”

The evolution and current use of invasive hemodynamic monitoring for predicting volume responsiveness during resuscitation, perioperative, and critical care

“…The relatively strong emphasis on CVP values that followed this trial may be related to clinicians' hesitancy about the role of the proprietary catheter used to measure ScVO 2 [42]. Another reason for this is that single and serial peripheral venous lactate measurements are as useful as ScVO 2 in assessing organ perfusion and response to resuscitation in trauma and septic shock [43][44][45].…”