Multi-bioresponsive silk fibroin-based nanoparticles with on-demand cytoplasmic drug release capacity for CD44-targeted alleviation of ulcerative colitis

Gou, Shuangquan; Yi, Huang; Wan, Ying; Ma, Yu; Zhou, Xin; Tong, Xiaoling; Huang, Jin; Kang, Yuejun; Pan, Guoqing; Dai, Fangyin; Xiao, Bo

doi:10.1016/j.biomaterials.2019.05.012

Cited by 185 publications

(122 citation statements)

References 53 publications

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“…However, these compounds often possess low aqueous solubility and extensive systemic metabolism, leading to a low therapeutic efficiency. To this end, FNPs prove their ability as a drug delivery system, which successfully incorporate numerous natural compounds such as curcumin (Gou et al, 2019;Xue et al, 2019), quercetin (Lozano-P erez et al, 2017), alpha mangostin (Pham et al, 2019a), triptolide (Ding et al, 2017), celastrol (Ding et al, 2017), and resveratrol (Lozano-P erez et al, 2014). In general, all these drug loaded FNPs demonstrated high entrapment efficiency, controllably sustained release profiles, increased drug solubility and stability, decreased drug degradation, reduced drug unwanted toxicity, as well as retained drug therapeutic efficiency, sometimes even enhanced it (Pham et al, 2019b).…”

Section: Small Molecule Deliverymentioning

confidence: 99%

“…Gou et al developed curcumin loaded FNPs functionalized with chondroitin sulfate as a multi-bioresponsive platform for the treatment of ulcerative colitis, using both oral and intravenous administrations (Gou et al, 2019). These spherical particles had an average size of 175.4 nm, a narrow size distribution, and a negative surface charge of À35.5 mV.…”

Section: Oral Administrationmentioning

confidence: 99%

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Fibroin nanoparticles: a promising drug delivery system

Phạm

Tiyaboonchai

2020

Drug Delivery

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Fibroin is a dominant silk protein that possesses ideal properties as a biomaterial for drug delivery. Recently, the development of fibroin nanoparticles (FNPs) for various biomedical applications has been extensively studied. Due to their versatility and chemical modifiability, FNPs can encapsulate different types of therapeutic compounds, including small and big molecules, proteins, enzymes, vaccines, and genetic materials. Moreover, FNPs are able to be administered both parenterally and non-parenterally. This review summaries basic information on the silk and fibroin origin and characteristics, followed by the up-to-date data on the FNPs preparation and characterization methods. In addition, their medical applications as a drug delivery system are in-depth explored based on several administrative routes of parenteral, oral, transdermal, ocular, orthopedic, and respiratory. Finally, the challenges and suggested solutions, as well as the future outlooks of these systems are discussed.

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Section: Small Molecule Deliverymentioning

confidence: 99%

Section: Oral Administrationmentioning

confidence: 99%

Fibroin nanoparticles: a promising drug delivery system

Phạm

Tiyaboonchai

2020

Drug Delivery

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“…The main limitations of small molecule antioxidants lie in their systemic distribution, rapid metabolism, and low retention at the diseased site, thereby resulting in low bioavailability in target tissues/cells. In this aspect, nanoparticles can protect the loaded small molecule antioxidants from hydrolysis, achieve site-specific delivery and controlled release of antioxidants at disease sites, and therefore improve their bioavailability ( Table 3) (Wang et al, 2015;Kang et al, 2016;Jung et al, 2018;Larrañaga et al, 2018;Gou et al, 2019). For example, our group fabricated a SOD/CAT-mimetic nanomedicine comprising H 2 O 2 -eliminating nanoparticles derived from a PBAP-conjugated β-CD material and a free radical scavenger Tempol .…”

Section: Drug-loaded Nanoparticles With Antioxidant Activitymentioning

confidence: 99%

“…Unfortunately, non-specific distribution and low retention of these compounds often results in multiple side effects. So far, a number of studies have reported the construction of orally available antioxidant nanoparticles for IBD therapy with high inflamed colon retention and therapeutic effects (Vong et al, 2012;Lamprecht, 2015;Alaarg et al, 2017;Bak et al, 2018;Gou et al, 2019;Kotla et al, 2019;Li S. et al, 2019;Schilrreff et al, 2019).…”

Section: Inflammatory Bowel Diseasementioning

confidence: 99%

Antioxidant Nanotherapies for the Treatment of Inflammatory Diseases

Chen

et al. 2020

Front. Bioeng. Biotechnol.

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Reactive oxygen species (ROS) are essential in regulating various physiological functions. However, overproduction of ROS is implicated in the pathogenesis of various inflammatory diseases. Antioxidant therapy has thus represented an effective strategy for the treatment of oxidative stress relevant inflammatory diseases. Conventional anti-oxidative agents showed limited in vivo effects owing to their non-specific distribution and low retention in disease sites. Over the past decades, significant achievements have been made in the development of antioxidant nanotherapies that exhibit multiple advantages such as excellent pharmacokinetics, stable anti-oxidative activity, and intrinsic ROS-scavenging properties. This review provides a comprehensive overview on recent advances in antioxidant nanotherapies, including ROS-scavenging inorganic nanoparticles, organic nanoparticles with intrinsic antioxidant activity, and drug-loaded anti-oxidant nanoparticles. We highlight the biomedical applications of antioxidant nanotherapies in the treatment of different inflammatory diseases, with an emphasis on inflammatory bowel disease, cardiovascular disease, and brain diseases. Current challenges and future perspectives to promote clinical translation of antioxidant nanotherapies are also briefly discussed.

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“…In fact, natural NPs offer a safer, more sustainable, and better economic drug delivery system. NPs made from natural polymers, including chitosan, sulfated polysaccharides (from marine algae), silk fibroin, and poly amino acids, have been extensively studied and reviewed for their anti-inflammatory potentials [11][12][13][14][15]. In this editorial, we will mainly focus on the new trend of applying novel edible plantand mammalian cell-derived NP drug delivery systems for IBD treatments.…”

Section: Introductionmentioning

confidence: 99%